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1. WO2000043783 - ASSAYS INVOLVING COLLOIDS AND NON-COLLOIDAL STRUCTURES

Publication Number WO/2000/043783
Publication Date 27.07.2000
International Application No. PCT/US2000/001504
International Filing Date 21.01.2000
Chapter 2 Demand Filed 23.08.2000
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
B82Y 15/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
G01N 2610/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2610Assays involving self-assembled monolayers [SAMs]
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/5438
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
54373involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
5438Electrodes
Applicants
  • MINERVA BIOTECHNOLOGIES CORPORATION [US/US]; 142 Church Street Newton, MA 02458, US (AllExceptUS)
  • BAMDAD, Cynthia, Carol [US/US]; US (UsOnly)
  • BAMDAD, R., Shoshana [US/US]; US (UsOnly)
Inventors
  • BAMDAD, Cynthia, Carol; US
  • BAMDAD, R., Shoshana; US
Agents
  • OYER, Timothy, J.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210, US
Priority Data
60/116,97523.01.1999US
60/132,28903.05.1999US
60/133,14807.05.1999US
60/133,77212.05.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ASSAYS INVOLVING COLLOIDS AND NON-COLLOIDAL STRUCTURES
(FR) INTERACTION ENTRE DES ESPÈCES IMMOBILISÉES SUR DES COLLOÏDES ET DES ESPÈCES EXISTANT SUR DES STRUCTURES COLLOÏDALES
Abstract
(EN)
The invention provides novel techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.
(FR)
La présente invention concerne de nouveaux procédés permettant de dériver des colloïdes avec des monocouches auto-assemblées. Cela offre la possibilité d'une grande diversité d'essais et notamment des études à interaction entre agents chimiques ou biochimiques. De tels colloïdes dérivés biologiquement, avec ou sans entités de signalisation, servent comme sonde recherchant des interactions avec des espèces existant sur des structures non colloïdales. L'invention comporte ainsi des techniques permettant d'immobiliser des particules colloïdales sur une grande diversité de structures non colloïdales. On a même la possibilité de munir de colloïdes diverses structures non colloïdales, y-compris des billes, ce qui permet de réaliser un essai détectable. Cela permet, dans de nombreux cas, des essais détectables à l'oeil nu, ainsi que des essais détectables par détermination automatisée d'une modification de l'interaction d'un rayonnement électromagnétique avec les colloïdes, et notamment l'absorption, la dispersion lumineuse, et analogue.
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