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1. WO2000043782 - REMOVAL OF PRIONS FROM BLOOD, PLASMA AND OTHER LIQUIDS

Publication Number WO/2000/043782
Publication Date 27.07.2000
International Application No. PCT/US1999/030167
International Filing Date 17.12.1999
Chapter 2 Demand Filed 30.06.2000
IPC
A61K 35/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
A61L 2/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
A61L 2/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
16using chemical substances
A61M 1/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B01D 15/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
B01D 43/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
43Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
CPC
A61L 2/0082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
0005for pharmaceuticals, biologicals or living parts
0082using chemical substances
A61M 1/3486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3472with treatment of the filtrate
3486Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
A61M 1/3618
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3618Magnetic separation
A61M 1/3679
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3679by absorption
A61M 2202/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2202Special media to be introduced, removed or treated
07Proteins
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 12th floor 1111 Franklin Street Oakland, CA 94607-5200, US (AllExceptUS)
  • PRUSINER, Stanley, B. [US/US]; US (UsOnly)
  • SAFAR, Jiri, G. [CZ/US]; US (UsOnly)
Inventors
  • PRUSINER, Stanley, B.; US
  • SAFAR, Jiri, G.; US
Agents
  • BOZICEVIC, Karl; Bozicevic, Field & Francis LLP Suite 200 200 Middlefield Road Menlo Park, CA 94025, US
Priority Data
09/235,37220.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REMOVAL OF PRIONS FROM BLOOD, PLASMA AND OTHER LIQUIDS
(FR) ELIMINATION DES PRIONS DU SANG, DU PLASMA ET D'AUTRES LIQUIDES
Abstract
(EN)
Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a substrate is coated with a prion complexing agent, such as a metal salt (e.g. sodium) of phosphotungstic acid. Blood or plasma passing through a column containing beads coated with prion complexing agent are rendered prion free. The beads may be comprised of a ferromagnetic core to facilitate removal of the beads from the sample.
(FR)
Cette invention se rapporte à des dispositifs tels que des colonnes à flux traversant, à des substrats tels que des perles polymères sphériques et à des procédés d'utilisation de ceux-ci pour éliminer les prions de n'importe quel échantillon liquide. A cet effet, une surface d'un substrat est recouverte d'un agent formant complexe avec les prions, tel qu'un sel métallique (par exemple sodium) d'acide phosphotungstique. Le sang ou le plasma traversant une colonne contenant de telles perles recouvertes de l'agent formant complexe avec les prions sont ainsi rendus exempts de tout prion. Lesdites perles peuvent être constituées par un noyau ferromagnétique visant à faciliter l'élimination des perles de l'échantillon.
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