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1. WO2000043750 - IMAGING OF TISSUE USING POLARIZED LIGHT

Publication Number WO/2000/043750
Publication Date 27.07.2000
International Application No. PCT/US2000/001764
International Filing Date 25.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 10/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
10Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
G01N 21/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
G01N 21/21 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/27 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
27using photo-electric detection
G01N 21/47 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
47Scattering, i.e. diffuse reflection
CPC
A61B 10/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
10Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis
A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
G01N 21/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
G01N 21/21
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/27
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
27using photo-electric detection
G01N 21/47
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
47Scattering, i.e. diffuse reflection
Applicants
  • NEWTON LABORATORIES, INC. [US/US]; Suite 4850 800 West Cummings Park Woburn, MA 01801, US (AllExceptUS)
  • FULGHUM, Stephen, F. [US/US]; US (UsOnly)
Inventors
  • FULGHUM, Stephen, F.; US
Agents
  • HOOVER, Thomas, O. ; Hamilton, Brook, Smith & Reynolds, P.C. Two Militia Drive Lexington, MA 02421, US
Priority Data
60/117,22125.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMAGING OF TISSUE USING POLARIZED LIGHT
(FR) IMAGERIE DE TISSUS AU MOYEN DE LUMIERE POLARISEE
Abstract
(EN)
The present invention relates to the differential detection of directly backscattered light from epithelial tissues in order to determine the cell nuclear size distribution for the purpose of detecting tissue dysplasia. Light directly backscattered from surface tissue is differentiated from the light backscattered from underlying tissue by means of polarization, angular distribution or both. Both point measurement embodiments and imaging embodiments are presented. Optical systems for delivery and collection of light include endoscopic and fiber optic systems.
(FR)
L'invention porte sur la détection différentielle de lumière directement rétrodiffusée à partir des tissus épithéliaux afin d'analyser la distribution de la dimension des noyaux cellulaires de manière à détecter les dysplasies dans le tissu. La lumière directement rétrodiffusée par le tissu superficiel est séparée de la lumière rétrodiffusée par les tissus sous-jacents au moyen d'une polarisation, d'une distribution angulaire ou de ces deux procédés à la fois. L'invention porte aussi bien sur des systèmes de mesure par points que sur des systèmes d'imagerie, et concerne également des systèmes optiques de diffusion et de captage de lumière comprenant des systèmes endoscopiques et des systèmes à fibre optique.
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