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1. (WO2000043552) MULTIFUNCTIONAL AND MULTISPECTRAL BIOSENSOR DEVICES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2000/043552 International Application No.: PCT/US2000/002051
Publication Date: 27.07.2000 International Filing Date: 25.01.2000
Chapter 2 Demand Filed: 22.08.2000
IPC:
C12Q 1/00 (2006.01) ,G01N 33/543 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
UT-BATTELLE, LLC [US/US]; P.O. Box 2008, MS-6498 Oak Ridge TN 37831, US (AllExceptUS)
VO-DINH, Tuan [US/US]; US (UsOnly)
Inventors:
VO-DINH, Tuan; US
Agent:
MOORE, Mark, D.; Williams, Morgan & Amerson, P.C. Suite 250 7676 Hillmont Houston, TX 77040, US
KEUSSEN, Christof; Glawe, Delfs, Moll & Partner Rothenbaumchaussee 58 D-20148 Hamburg, DE
Priority Data:
09/236,75825.01.1999US
Title (EN) MULTIFUNCTIONAL AND MULTISPECTRAL BIOSENSOR DEVICES AND METHODS OF USE
(FR) BIOCAPTEURS MULITISPECTRE ET MULTIFONCTIONS, ET LEURS PROCEDES D'UTILISATION
Abstract:
(EN) GB0000079 are advanced multifunctional biochip devices capable of specifically detecting and quantitating multiple biomolecular target compounds, such as polypeptides, polynucleotides, and other intracellular and extracellular biomolecules. In illustrative embodiments, the miniaturized multifunctional biosensor device comprises multiple biological sensing elements, excitation micro-lasers, a sampling waveguide equipped with optical fluorescence detectors, integrated electro-optics, a bio-telemetric radio frequency signal generator, and a plurality of molecular probes, all contained on a single integrated circuit, or 'biochip'. The biochip is suitable for multi-gene analysis, and multi-peptide detection, as well as simultaneous detection and quantitation of polynucleotide and polypeptide species using a single biochip device. Also disclosed are methods that permit rapid, large-scale, and cost-effective production of such biochip devices, as well as their use in the detection and quantitation of multiple species in a single mixed biological sample.
(FR) L'invention concerne des dispositifs avancés sous forme de biopuce multifonctions, capables de détecter et de quantifier de manière spécifique plusieurs composés cibles biomoléculaires, tels que des polypeptides, des polynucléotides, et d'autres biomolécules intracellulaires et extracellulaires. Selon des modes de réalisation types, le biocapteur miniaturisé multifonctions comprend plusieurs éléments biologiques de détection, des microlasers d'excitation, un guide d'ondes d'échantillonnage équipé de détecteurs optiques de fluorescence, des dispositifs électro-optiques intégrés, un générateur de signaux HF biotélémétrique, et plusieurs sondes moléculaires, le tout étant disposé sur un seul circuit intégré ou sur une biopuce. Cette biopuce convient parfaitement pour l'analyse de plusieurs gènes et la détection de plusieurs peptides, ainsi que pour la détection et la quantification simultanées des espèces de polynucléotide et de polypeptide utilisant un seul dispositif sous forme de biopuce. L'invention concerne également des techniques permettant de produire rapidement, sur une grande échelle, et à bon marché les dispositifs sous forme de biopuce, ainsi que leur utilisation pour détecter et quantifier plusieurs espèces dans un seul échantillon biologique mélangé.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1151139US6743581CA2358699AU2000027400