Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Sunday 05.04.2020 at 10:00 AM CEST
Settings

Settings

1. WO2000043549 - LIPOPHILIC QUENCHING OF VIRAL INACTIVATING AGENTS

Publication Number WO/2000/043549
Publication Date 27.07.2000
International Application No. PCT/US2000/001768
International Filing Date 24.01.2000
Chapter 2 Demand Filed 16.08.2000
IPC
C12N 7/06 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
06by chemical treatment
CPC
C12N 2700/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2700Viruses
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
C12Q 2549/125
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2549Reactions characterised by the features used to influence the efficiency or specificity
10the purpose being that of reducing false positive or false negative signals
125using sterilising/blocking agents, e.g. albumin
Applicants
  • V.I. TECHNOLOGIES, INC. [US/US]; 45 Moulton Street Cambridge, MA 02138, US
Inventors
  • EDSON, Clark, M.; US
  • PURMAL, Andrei, A.; US
  • ACKERMAN, Samuel, K.; US
Agents
  • CLARK, Paul, T.; Clark & Elbing LLP 176 Federal Street Boston, MA 02110, US
Priority Data
09/237,13625.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIPOPHILIC QUENCHING OF VIRAL INACTIVATING AGENTS
(FR) EXTINCTION PAR LIPOPHILES D'AGENTS D'INACTIVATION VIRALE
Abstract
(EN)
Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of tehyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.
(FR)
L'invention concerne des procédés et des compositions permettant d'inactiver et d'extraire les contaminants d'une composition biologique. Ces procédés comprennent les étapes suivantes: (a) on met en contact la composition biologique avec un agent d'inactivation comprenant un groupe aziridino tel que l'éthylène-imine, un oligomère d'éthylène-imine, ou un sel dérivé halo de chaque élthylène-imine ou un oligomère d'éthylène-imine, une partie de cet agent réagit avec le contaminant de manière à l'inactiver et une autre partie de l'agent reste inaltéré; (b) on met le produit obtenu à l'étape (a) en contact avec un agent d'extinction lipophile comprenant au moins un groupe d'extinction fixé sur un groupe lipophile, dans des conditions, et pendant une durée permettant à l'agent inaltéré de former une liaison covalente avec le groupe d'extinction; et (c) on sépare l'agent lipophile et l'agent d'inactivation désactivé de la composition biologique.
Latest bibliographic data on file with the International Bureau