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1. WO2000043548 - THERAPEUTIC AND DIAGNOSTIC APPLICATIONS OF PROSTATIC ACID PHOSPHATASE IN PROSTATE CANCER

Publication Number WO/2000/043548
Publication Date 27.07.2000
International Application No. PCT/US2000/001599
International Filing Date 21.01.2000
Chapter 2 Demand Filed 18.08.2000
IPC
A61K 38/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
A61K 38/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
465acting on ester bonds (3.1), e.g. lipases, ribonucleases
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
C12Y 301/03002
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
301Hydrolases acting on ester bonds (3.1)
03Phosphoric monoester hydrolases (3.1.3)
03002Acid phosphatase (3.1.3.2)
G01N 2333/914
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
Applicants
  • BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US/US]; Regents Hall 3835 Holdrege Street Lincoln, NE 68598, US (AllExceptUS)
  • LIN, Ming-Fong [US/US]; US (UsOnly)
Inventors
  • LIN, Ming-Fong; US
Agents
  • KLANN, Ellen, M. ; Dann, Dorfman, Herrell and Skillman Suite 720 1601 Market Street Philadelphia, PA 19103, US
Priority Data
60/116,55121.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC AND DIAGNOSTIC APPLICATIONS OF PROSTATIC ACID PHOSPHATASE IN PROSTATE CANCER
(FR) APPLICATIONS THERAPEUTIQUES ET DIAGNOSTIQUES DE LA PHOSPHATASE ACIDE PROSTATIQUE POUR LES CANCERS DE LA PROSTATE
Abstract
(EN)
Presented is a therapeutic method to treat prostate carcinomas in mammals comprising the administration of cellular PAcP protein. Also presented is a method to diagnose androgen-insensitive prostate carcinomas by determining the expression level of cellular PAcP in the prostate carcinomas, a decrease in expression being indicative of androgen-insensitivity. A promoter region that is specifically expressed in prostate tissue is presented, as is a xenograft animal model that mimics human prostate carcinomas in the expression of cellular PAcP.
(FR)
La présente invention concerne un traitement des cancers de la prostate chez des mammifères, qui consiste dans l'administration de la protéine PacP cellulaire. L'invention concerne également une méthode de diagnostic des cancers de la prostate insensibles aux androgènes, qui consiste à déterminer le niveau d'expression de la protéine PacP cellulaire dans lesdits cancers, une baisse de l'expression indiquant une insensibilité aux androgènes. Est présentée une région promoteur qui s'exprime spécifiquement dans le tissu prostatique, comme par exemple un modèle animal de xenogreffe qui imite des cancers de la prostate chez l'homme dans l'expression de la protéine PacP cellulaire.
Also published as
Latest bibliographic data on file with the International Bureau