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1. WO2000043533 - PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITORS

Publication Number WO/2000/043533
Publication Date 27.07.2000
International Application No. PCT/JP2000/000245
International Filing Date 20.01.2000
Chapter 2 Demand Filed 18.08.2000
IPC
C12P 7/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
62Carboxylic acid esters
C12P 17/06 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
06containing a six-membered hetero ring, e.g. fluorescein
CPC
C12P 17/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
06containing a six-membered hetero ring, e.g. fluorescein
C12P 7/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
62Carboxylic acid esters
Applicants
  • KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome Chiyoda-ku Tokyo 100-8185, JP (AllExceptUS)
  • HASHIMOTO, Shin-ichi [JP/JP]; JP (UsOnly)
  • YONETANI, Yoshiyuki [JP/JP]; JP (UsOnly)
  • OZAKI, Akio [JP/JP]; JP (UsOnly)
Inventors
  • HASHIMOTO, Shin-ichi; JP
  • YONETANI, Yoshiyuki; JP
  • OZAKI, Akio; JP
Priority Data
11/1239220.01.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITORS
(FR) PROCEDE DE PRODUCTION D'INHIBITEURS DE LA HMG COA-REDUCATASE
Abstract
(EN)
A process for producing compounds (II-a) or compounds (II-b), which are respectively hydroxylated products of compounds represented by general formula (I-a) (here in after referred to as the compounds (I-a)) or closed lactone derivatives thereof (hereinafter referred to as the compounds (I-b)). In formula (I-a) R1 represents hydrogen, optionally substituted alkyl or an alkali metal; and R2 represents optionally substituted alkyl or optionally substituted aryl. This process is characterized by treating in an aqueous medium the compounds (I-a) or (I-b) with an enzyme source comprising a microorganism having an activity of hydroxylating the compounds (I-a) or (I-b), having no sporulability and showing no hyphal growth, or an optionally processed culture of the microorganism and collecting the compounds (II-a) or (II-b) from the aqueous medium.
(FR)
L'invention concerne un procédé de production de composés (II-a) ou (II-b), qui sont respectivement des produits hydroxylés de composés de la formule générale (I-a) (ci-après dénommés composés (I-a)) ou des dérivés de lactone fermés issus de ces composés (ci-après dénommés composés (I-b)). Dans ladite formule, R1 est hydrogène, alkyle éventuellement substitué ou un métal alcalin; et R2 est alkyle éventuellement substitué ou aryle éventuellement substitué. Le procédé consiste à traiter les composés (I-a) ou (I-b) dans un milieu aqueux, au moyen d'une source enzymatique contenant un micro-organisme ayant une activité d'hydroxylation des composés (I-a) ou (I-b) ou ne possédant aucune propriété de sporulation ou de croissance fongique. Le procédé consiste autrement à traiter lesdits composés au moyen d'une culture du micro-organisme éventuellement épurée aux fins de recueillir les composés (II-a) ou (II-b) dudit milieu aqueux.
Also published as
CZPV2001-2622
ININ/PCT/2001/1120/CHE
Latest bibliographic data on file with the International Bureau