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1. WO2000043514 - HUMAN ACID SENSING ION CHANNEL AND USES THEREOF

Publication Number WO/2000/043514
Publication Date 27.07.2000
International Application No. PCT/US2000/001601
International Filing Date 21.01.2000
Chapter 2 Demand Filed 21.08.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street Cambridge, MA 02139, US
Inventors
  • CURTIS, Rory, A., J.; US
Agents
  • MANDRAGOURAS, Amy, E.; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109 , US
Priority Data
09/235,69822.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN ACID SENSING ION CHANNEL AND USES THEREOF
(FR) CANAL IONIQUE DETECTANT LES ACIDES ET SES UTILISATIONS
Abstract
(EN)
The invention provides isolated nucleic acids molecules, designated ASIC4 nucleic acid molecules, which encode novel ASIC family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ASIC4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ASIC4 gene has been introduced or disrupted. The invention still further provides isolated ASIC4 proteins, fusion proteins, antigenic peptides and anti-ASIC4 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
(FR)
Cette invention concerne des molécules d'acide nucléique isolées, dites molécules d'acide nucléique ASIC4, qui codent pour de nouveaux membres de la famille ASIC. Cette invention concerne également des molécules d'acide nucléique antisens, des vecteurs recombinants renfermant des molécules d'acide nucléique ASIC4, des cellules hôtes dans lesquelles ont été introduits des vecteurs d'expression, et des animaux transgéniques non humains dans lesquels un gène ASIC4 a été introduit ou invalidé. De plus l'invention concerne des protéines ASIC4 isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-ASIC4, ainsi que des méthodes de diagnostic faisant intervenir les compositions selon l'invention.
Also published as
Latest bibliographic data on file with the International Bureau