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1. WO2000043510 - RAS ACTIVATOR NUCLEIC ACID MOLECULES - GUANINE NUCLEOTIDE RELEASING FACTOR GRF4, POLYPEPTIDES AND METHODS OF USE

Publication Number WO/2000/043510
Publication Date 27.07.2000
International Application No. PCT/CA2000/000042
International Filing Date 20.01.2000
Chapter 2 Demand Filed 21.08.2000
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP [CA/CA]; Suite 5726 555 University Avenue Toronto, Ontario M5G 1X8, CA (AllExceptUS)
  • ROTIN, Daniela [CA/CA]; CA (UsOnly)
  • PHAM, Nam [CA/CA]; CA (UsOnly)
Inventors
  • ROTIN, Daniela; CA
  • PHAM, Nam; CA
Agents
  • DEETH WILLIAMS WALL; National Bank Building Suite 400 150 York Street Toronto, Ontario M5H 3S5, CA
Priority Data
2,259,83020.01.1999CA
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RAS ACTIVATOR NUCLEIC ACID MOLECULES - GUANINE NUCLEOTIDE RELEASING FACTOR GRF4, POLYPEPTIDES AND METHODS OF USE
(FR) MOLECULES D'ACIDES NUCLEIQUES ET POLYPEPTIDES D'ACTIVATEURS DE RAS, ET TECHNIQUES D'EMPLOI
Abstract
(EN)
The invention is a Guanine Releasing Factor, GRF4 nucleic acid molecule and its corresponding protein which has an important role in cell signaling. The invention also includes biologically functional equivalent nucleic acid molecules and proteins. The invention also relates to methods of using these nucleic acid sequences and proteins in medical treatments and drug screening.
(FR)
L'invention concerne une molécule d'acides nucléiques GRF4 et la protéine correspondante dont le rôle de signalisation de cellules est important. L'invention traite également de molécules d'acides nucléiques et de protéines équivalentes biologiquement fonctionnelles. Elle concerne enfin des techniques d'emploi de ces séquences d'acides nucléiques et protéines dans des traitements médicaux et criblages de médicaments.
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