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1. WO2000043505 - PROTEASE WITH TWO ASPARTATE RADICALS IN THE CATALYTICALLY ACTIVE STRUCTURE

Publication Number WO/2000/043505
Publication Date 27.07.2000
International Application No. PCT/EP2000/000390
International Filing Date 19.01.2000
Chapter 2 Demand Filed 08.02.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/50 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
C12N 9/64 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
C12Q 1/37 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
C12N 9/6478
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6478Aspartic endopeptidases (3.4.23)
C12Q 1/37
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
34involving hydrolase
37involving peptidase or proteinase
Applicants
  • MEMOREC MEDICAL MOLECULAR RESEARCH COLOGNE STOFFEL GMBH [DE/DE]; Stöckheimer Weg 1 D-50829 Köln, DE (AllExceptUS)
  • HOFMANN, Kay [DE/DE]; DE
Inventors
  • HOFMANN, Kay; DE
Agents
  • MEYERS, Hans-Wilhelm ; Von Kreisler Selting Werner Postfach 10 22 41 D-50462 Köln, DE
Priority Data
199 02 550.922.01.1999DE
199 25 946.108.06.1999DE
199 29 115.224.06.1999DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) PROTEASE MIT ZWEI ASPARTATRESTEN IN DER KATALYTISCH AKTIVEN STRUKTUR
(EN) PROTEASE WITH TWO ASPARTATE RADICALS IN THE CATALYTICALLY ACTIVE STRUCTURE
(FR) PROTEASE
Abstract
(DE)
Protease mit zwei Aspartatresten in einer katalytisch aktiven Struktur, wobei ein erster Aspartatrest in einem Motiv X1GX2GD liegt und ein zweiter Aspartatrest in einem Motiv X3X4DX5 liegt, wobei X1, X2, X3 und X5 unabhängig voneinander ausgewählt werden aus Ala, Val, Leu, Met und Ile und X4 eine aromatische Aminosäure ist, und die Motive X1GX2GD und X3X4DX5 in einer Transmembranregion liegen.
(EN)
The invention relates to protease with two aspartate radicals in a catalytically active structure, a first aspartate radical being in a sequence X1GX2GD and a second aspartate radical being in a sequence X3X4DX5, X1, X2, X3 and X5 being selected independently of each other from the following: Ala, Val, Leu, Met and Ile; and X4 being an aromatic amino acid. The sequences X1GX2GD and X3X4DX5 lie in a transmembrane region.
(FR)
L'invention concerne une protéase comportant deux restes aspartate dans une structure catalytiquement active, un premier reste aspartate se situant dans un motif X1GX2GD et un deuxième reste aspartate se situant dans un motif X3X4DX5. La protéase selon l'invention est caractérisée en ce que X1, X2, X3 et X5 pouvent être choisis indépendamment les uns des autres parmi Ala, Val, Leu, Met et Ile, en ce que X4 est un acide aminé aromatique et en ce que les motifs X1GX2GD et X3X4DX5 se situent dans une région transmembranaire.
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