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1. WO2000043408 - STEROID SULFATASE INHIBITORS AND METHODS FOR MAKING AND USING THE SAME

Publication Number WO/2000/043408
Publication Date 27.07.2000
International Application No. PCT/US2000/001723
International Filing Date 24.01.2000
Chapter 2 Demand Filed 21.08.2000
IPC
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 71/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopentahydrophenanthrene skeleton is condensed with a heterocyclic ring
CPC
C07J 41/0005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0005the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
C07J 41/0011
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0005the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
0011Unsubstituted amino radicals
C07J 41/0066
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
0066the 17-beta position being substituted by a carbon atom forming part of an amide group
C07J 41/0072
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033not covered by C07J41/0005
0072the A ring of the steroid being aromatic
C07J 71/0094
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
0073Sulfur-containing hetero ring
0094containing sulfur and nitrogen
Applicants
  • DUQUESNE UNIVERSITY OF THE HOLY GHOST [US/US]; 505 Administration Building Pittsburgh, PA 15282, US
  • KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1 Ohtemachi, 1-chome Chiyoda-ku Tokyo 100-8185, JP
Inventors
  • LI, Pui-Kai; US
  • AKINAGA, Shiro; JP
  • MURAKATA, Chikara; JP
Agents
  • MEYERS, Diane, R.; Eckert Seamans Cherin & Mellott, LLC 600 Grant Street 44th floor Pittsburgh, PA 15219, US
Priority Data
09/236,84225.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STEROID SULFATASE INHIBITORS AND METHODS FOR MAKING AND USING THE SAME
(FR) STEROIDES INHIBITEURS DE SULFATASE ET PROCEDES DE FABRICATION ET D'UTILISATION DE CES DERNIERS
Abstract
(EN)
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.
(FR)
La présente invention concerne de nouveaux composés inhibiteurs de sulfatase utilisés dans le traitement de maladies dépendant des oestrogènes. Les composés précités comprennent généralement un noyau stéroïde substitué en position C17. L'invention se rapporte également à des procédés de synthèse et d'utilisation de ces composés dans le traitement thérapeutique et/ou prophylactique d'un patient.
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