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1. WO2000043399 - 3,6-DISUBSTITUTED PENAM SULFONE DERIVATIVES AS ANTIBACTERIALS

Publication Number WO/2000/043399
Publication Date 27.07.2000
International Application No. PCT/US2000/001630
International Filing Date 26.01.2000
Chapter 2 Demand Filed 26.07.2000
IPC
C07D 499/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
499Heterocyclic compounds containing 4-thia-1-azabicyclo heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
CPC
C07D 499/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
499Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Applicants
  • AMERICAN CYANAMID COMPANY [US/US]; Five Giralda Farms Madison, NJ 07940-0874, US
Inventors
  • LIN, Yang-I; US
  • BITHA, Panayota; US
  • LI, Zhong; US
  • FRANCISCO, Gerardo, DelaCruz; US
Agents
  • NAGY, Michael, R.; American Home Products Corporation Patent Law Dept. - 2B One Campus Drive Parsippany, NJ 07054 , US
  • WILEMAN, David Francis; CONNELLY, Michael John; WALTERS, Philip Bernard William; MANNION, Sally Kim; BROWN, Keith John Symons and TALBOTT, Dawn Jacqueline; c/o Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berks SL6 0PH, GB
Priority Data
09/237,72626.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3,6-DISUBSTITUTED PENAM SULFONE DERIVATIVES AS ANTIBACTERIALS
(FR) DERIVES DE PENAME SULFONE 3,6-DISUBSTITUES COMME ANTIBACTERIENS
Abstract
(EN)
Compounds are provided having formulae (I) and (II) wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group; X is CH or NH; R3 is cyano, methoxy, or acetamido; R1 is hydrogen, alkyl, a negative charge, a cation selected from the group consisting of sodium, potassium and tetraalkylammonium and acyloxyalkyl, or alkoxycarbonyloxyalkyl; and R2 is hydrogen, acyl, trisubstituted silyl carbamoyl or an amino acid residue; or pharmaceutically acceptable salts thereof.
(FR)
L'invention concerne des composés représentés par les formules (I) et (II), dans lesquelles n vaut 0 ou 1, et si n=1, R est un noyau hétérocyclique à 5 ou 6 chaînons, hydroxy, halogène, oxo, carbamoyle, alcoxy, ou amino disubstitué ; si n=0, R est ester, cyano ou un groupe amide; X est CH ou NH; R3 est cyano, méthoxy, ou acétamido; R1 est hydrogène, alkyle, une charge négative, un cation sélectionné dans le groupe constitué par du sodium, du potassium, un tétraalkylammonium et un acyloxyalkyle, ou un alcoxycarbonyloxyalkyle; and R2 est hydrogène, acyle, un carbamoyle de silyle trisubstitué ou un résidu d'acide aminé; ou des sels pharmaceutiquement acceptables de ces composés.
Also published as
CZPV2001-2691
GE6069/1
ININ/PCT/2001/534/KOL
NO20013640
NZ511959
SK10142001
SK200101014
TR2001/02133
ZA200104323
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