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1. WO2000043394 - SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF

Publication Number WO/2000/043394
Publication Date 27.07.2000
International Application No. PCT/CZ2000/000002
International Filing Date 25.01.2000
Chapter 2 Demand Filed 15.08.2000
IPC
C07D 473/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
C07D 473/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
26with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32Nitrogen atom
C07D 473/34 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
26with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32Nitrogen atom
34attached in position 6, e.g. adenine
C07D 473/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
40with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 473/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
C07D 473/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
26with an oxygen, sulfur or nitrogen atom directly attached in position 2 or 6, but not in both
32Nitrogen atom
C07D 473/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
26with an oxygen, sulfur or nitrogen atom directly attached in position 2 or 6, but not in both
32Nitrogen atom
34attached in position 6, e.g. adenine
C07D 473/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
40with halogen atoms or perhalogeno-alkyl radicals directly attached in positions 2 or 6
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • ÚSTAV EXPERIMENTÁLNÍ BOTANIKY AV CR [CZ/CZ]; Rozvojová 135 160 00 Praha 6, CZ (AllExceptUS)
  • LACHEMA, A.S. [CZ/CZ]; Karásek 1 621 33 Brno, CZ (AllExceptUS)
  • HANUŠ, Jan [CZ/CZ]; CZ (UsOnly)
  • KRYŠtof, Vladimír [CZ/CZ]; CZ (UsOnly)
  • HAJDÚCH, Marián [CZ/CZ]; CZ (UsOnly)
  • VESELÝ, Jaroslav [CZ/CZ]; CZ (UsOnly)
  • STRNAD, Miroslav [CZ/CZ]; CZ (UsOnly)
Inventors
  • HANUŠ, Jan; CZ
  • KRYŠtof, Vladimír; CZ
  • HAJDÚCH, Marián; CZ
  • VESELÝ, Jaroslav; CZ
  • STRNAD, Miroslav; CZ
Agents
  • KUBÁT, Jan; Traplová Hakr Kubát Law and Patent Offices Prístavní 24 P.O. Box 38 170 00 Praha 7, CZ
Priority Data
PV 273-9926.01.1999CZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF
(FR) DERIVES HETEROCYCLIQUES D'AZOTE SUBSTITUE ET LEUR UTILISATION PHARMACEUTIQUE
Abstract
(EN)
This invention relates to new substituted nitrogen heterocyclic derivatives having cytostatic, anticancer, antimitotic, antineurogenerative, immunosuppressive and antimicrobial effects. This invention also relates to the methods for preparation of these derivatives, the use of the compounds as drugs, the pharmaceutical composition and combined pharmaceutical application form comprising an effective dose of a claimed compound and the use of these derivatives for drug production.
(FR)
L'invention concerne de nouveaux dérivés hétérocycliques d'azote substitué présentant des effets cytostatiques, anticancéreux, antimitotiques, antineurodégénératifs, immunosuppresseurs et antimicrobiens. L'invention concerne également des méthodes de préparation de ces dérivés, l'utilisation des composés en tant que médicaments, la composition pharmaceutique et la forme d'application pharmaceutique combinée comprenant une dose efficace d'un composé revendiqué ainsi que l'utilisation de ces dérivés dans la fabrication de médicaments.
Also published as
Latest bibliographic data on file with the International Bureau