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1. WO2000043391 - SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION

Publication Number WO/2000/043391
Publication Date 27.07.2000
International Application No. PCT/FR2000/000137
International Filing Date 21.01.2000
Chapter 2 Demand Filed 14.08.2000
IPC
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • PIERRE FABRE MEDICAMENT [FR/FR]; 45, place Abel Gance F-92100 Boulogne-Billancourt, FR (AllExceptUS)
  • RIEU, Jean-Pierre [FR/FR]; FR (UsOnly)
  • PATOISEAU, Jean-François [FR/FR]; FR (UsOnly)
  • JOHN, Gareth [GB/FR]; FR (UsOnly)
  • LEGRAND, Bruno [FR/FR]; FR (UsOnly)
  • VERSCHEURE, Yvan [FR/FR]; FR (UsOnly)
Inventors
  • RIEU, Jean-Pierre; FR
  • PATOISEAU, Jean-François; FR
  • JOHN, Gareth; FR
  • LEGRAND, Bruno; FR
  • VERSCHEURE, Yvan; FR
Agents
  • MARTIN, Jean-Jacques ; Cabinet Regimbeau 20, rue de Chazelles F-75847 Paris Cedex 17, FR
Priority Data
99/0070622.01.1999FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) SUBSTITUTED 1-(PIERIDIN-4-YL)-3-(ARYL) ISOTHIOUREAS THEIR PREPARATION AND THERAPEUTIC APPLICATION
(FR) 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREES SUBSTITUEES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
Abstract
(EN)
The invention concerns novel substituted N-benzo(thia/oxa)zines-2-yl-1-arylalkyloxyalkyl-4-piperidinamine, their preparation and their therapeutic use. The invention concerns compounds of formula (I) wherein: X represents an oxygen or sulphur atom; Y represents either an alkylene radical, branched or not and containing 2 to 6 carbon atoms or a CH2-CH(OH)-CH2- radical; R represents a hydrogen, an alkyl radical, branched or not and containing 1 to 7 carbon atoms; R1 to R6, identical or different, represent a hydrogen, a saturated or unsaturated alkyl, branched or not and containing 1 to 5 carbon atoms, a saturated or unsaturated alkyloxy, branched or not and containing 1 to 5 carbon atoms, a halogeno, nitro, hydroxy, acyl or acyloxy group comprising 2 to 3 carbon atoms, an alkylamino group containing 1 to 5 carbon atoms, a trifluoro methyl or trifluoro methoxyl group; n is an integer ranging from 1 to 6 inclusively; and their pure enantiomers or their mixtures, the therapeutically acceptable mineral and organic salts of the compounds of formula (I) and their possible hydrates.
(FR)
L'invention concerne de nouvelles N-benzo(thia/oxa)zines-2-yl-1-arylalcoyloxyalkyl-4-pipéridinamine substituées, leur préparation et leur utilisation en thérapeutique. Ces composés répondent à la formule (I): dans laquelle: X représente un atome d'oxygène ou de soufre, Y représente soit: un radical alcoylène, ramifié ou non renfermant de 2 à 6 atomes de carbone, un radical - CH2-CH(OH)-CH2-, R représente: un hydrogène, un radical alcoyle saturé ou non, ramifié ou non comportant de 1 à 7 atomes de carbone, R1 à R6 égaux ou différents représentent un hydrogène, un alcoyle ramifié ou non, saturé ou non renfermant de 1 à 5 atomes de carbone, un alcoyloxy ramifié ou non saturé ou non renfermant de 1 à 5 atomes de carbone, un groupement halogéno, nitro, hydroxy, acyle ou acyloxy comportant de 2 à 3 atomes de carbone, un groupement d'alcoylamino renfermant de 1 à 5 atomes de carbone, un groupement trifluoro méthyle ou trifluoro méthoxyle, n est un nombre entier pouvant varier de 1 à 6 inclus ainsi que leurs énantiomères purs ou leurs mélanges, et les sels minéraux ou organiques thérapeutiquement acceptables des composés de formule (I) et leurs hydrates éventuels.
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