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1. WO2000043385 - HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Publication Number WO/2000/043385
Publication Date 27.07.2000
International Application No. PCT/JP2000/000348
International Filing Date 25.01.2000
Chapter 2 Demand Filed 24.08.2000
IPC
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • ZENYAKU KOGYO KABUSHIKI KAISHA [JP/JP]; 2-9, Nihonbashi-Muromachi 3-chome Chuo-ku Tokyo 103-0022, JP (AllExceptUS)
  • KAWASHIMA, Seiichiro [JP/JP]; JP (UsOnly)
  • MATSUNO, Toshiyuki [JP/JP]; JP (UsOnly)
  • YAGUCHI, Shinichi [JP/JP]; JP (UsOnly)
  • TSUCHIDA, Yoshio [JP/JP]; JP (UsOnly)
  • SASAHARA, Hiroya [JP/JP]; JP (UsOnly)
  • WATANABE, Tetsuo [JP/JP]; JP (UsOnly)
  • INABA, Masahiro [JP/JP]; JP (UsOnly)
Inventors
  • KAWASHIMA, Seiichiro; JP
  • MATSUNO, Toshiyuki; JP
  • YAGUCHI, Shinichi; JP
  • TSUCHIDA, Yoshio; JP
  • SASAHARA, Hiroya; JP
  • WATANABE, Tetsuo; JP
  • INABA, Masahiro; JP
Agents
  • YAMADA, Tsunemitsu ; 2nd Yahagi Bldg. 5-3, Uchikanda 3-chome Chiyoda-ku Tokyo 101-0047, JP
Priority Data
11/1621625.01.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
(FR) COMPOSES HETEROCYCLIQUES ET AGENTS ANTITUMORAUX LES COMPRENANT EN TANT QUE PRINCIPE ACTIF
Abstract
(EN)
Heterocyclic compounds represented by general formula (I) wherein benzimidazole is attached as a substituent to s-triazine or pyrimidine, wherein X and Y represent each nitrogen, or one of X and Y represents nitrogen while the other represents C-R3 (wherein R3 represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, carboxy(C1-6 alkyl) or C1-6 alkoxycarbonyl(C1-6 alkyl)); R1 represents morpholino or pyrrolidinyl; and R2 represents morpholino, thiomorpholino, pyrrolidinyl, aziridinyl, piperazinyl, azetidinyl, oxazolidinyl or perhydrooxazepinyl, provided that when R1 and R2 are both unsubstituted morpholino, then Y is C-R3 wherein R3 is C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, carboxy(C1-6 alkyl) or C1-6 alkoxycarbonyl(C1-6 alkyl).
(FR)
La présente invention concerne des composés hétérocycliques correspondant à la formule générale (I) dans lequel du benzimidazole est lié an tant que substituant à de la s-triazine or de la pyrimidine, où X et Y représentent chacun l'azote, ou l'un de X et Y représente l'azote tandis que l'autre représente C-R3 (où R3 représente l'hydrogène, alkyle en C1-6, alcoxy en C1-6, alkylthio en C1-6, carboxy(alkyle en C1-6) ou alcoxycarbonyle en C1-6 (alkyle en C1-6); R1 représente morpholino ou pyrrolidinyle; R2 représente morpholino, thiomorpholino, pyrrolidinyle, aziridinyle, piperazinyle, azetidinyle, oxazolidinyle ou perhydrooxazepinyle, à condition que lorsque R1 et R2 représentent tous les deux un morpholino non-substitué, alors Y est C-R3, où R3 est un alkyle en C1-6, alcoxy C1-6, alkylthio en C1-6, carboxy(alkyle en C1-6) ou alcoxycarbonyle (alkyle en C1-6).
Also published as
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