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1. WO2000043354 - MULTICYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

Publication Number WO/2000/043354
Publication Date 27.07.2000
International Application No. PCT/US2000/001604
International Filing Date 21.01.2000
Chapter 2 Demand Filed 14.08.2000
IPC
C07C 233/63 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
57having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
63having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C07C 237/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
22having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
C07C 255/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
60at least one of the singly-bound nitrogen atoms being acylated
C07C 271/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07C 271/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
40having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
42with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 275/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of urea groups bound to acyclic carbon atoms
06of an acyclic and saturated carbon skeleton
16being further substituted by carboxyl groups
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard South San Francisco, CA 94080, US (AllExceptUS)
  • GRANT, Francine, S. [FR/US]; US (UsOnly)
  • JOHNSON, Bradley, S. [US/US]; US (UsOnly)
  • PLEISS, Michael, A. [US/US]; US (UsOnly)
  • THORSETT, Eugene, D. [US/US]; US (UsOnly)
Inventors
  • GRANT, Francine, S.; US
  • JOHNSON, Bradley, S.; US
  • PLEISS, Michael, A.; US
  • THORSETT, Eugene, D.; US
Agents
  • SWISS, Gerald, F. ; Burns, Doane, Swecker & Mathis, L.L.P. P.O. Box 1404 Alexandria, VA 22313-1404, US
Priority Data
60/116,73522.01.1999US
60/117,74329.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTICYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
(FR) COMPOSES INHIBANT L'ADHESION LEUCOCYTAIRE PROVOQUEE PAR VLA-4
Abstract
(EN)
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR)
Cette invention concerne des composés se liant à VLA-4. Certains de ces composés se caractérisent également par une adhésion leucocytaire, en particulier par une adhésion leucocytaire provoquée par VLA-4. Ces composés conviennent pour le traitement de maladies inflammatoires chez des mammifères, l'homme notamment, telles qu'asthme, maladie d'Alzheimer, athérosclérose, syndrome démentiel du SIDA, diabète, maladie intestinale inflammatoire, polyarthrite rhumatoïde, transplantations tissulaires, métastases tumorales et ischémie myocardique. Ces composés peuvent également être administrés pour le traitement de maladies inflammatoires du cerveau telles que la sclérose en plaques.
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