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1. WO2000043041 - MEDICINAL COMPOSITIONS WITH IMPROVED ORAL ABSORPTION

Publication Number WO/2000/043041
Publication Date 27.07.2000
International Application No. PCT/JP2000/000251
International Filing Date 20.01.2000
Chapter 2 Demand Filed 06.07.2000
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 47/32 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
CPC
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 9/1635
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1635obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Applicants
  • YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-honcho 2-chome Chuo-ku, Tokyo 103-8411, JP (AllExceptUS)
  • WATANABE, Shunsuke [JP/JP]; JP (UsOnly)
  • SAKO, Kazuhiro [JP/JP]; JP (UsOnly)
  • TAKEMURA, Shigeo [JP/JP]; JP (UsOnly)
  • KONDO, Hiromu [JP/JP]; JP (UsOnly)
  • SAWADA, Toyohiro [JP/JP]; JP (UsOnly)
  • YOSHIHARA, Keiichi [JP/JP]; JP (UsOnly)
  • YOSHIOKA, Tatsunobu [JP/JP]; JP (UsOnly)
  • KATSUMA, Masataka [JP/JP]; JP (UsOnly)
Inventors
  • WATANABE, Shunsuke; JP
  • SAKO, Kazuhiro; JP
  • TAKEMURA, Shigeo; JP
  • KONDO, Hiromu; JP
  • SAWADA, Toyohiro; JP
  • YOSHIHARA, Keiichi; JP
  • YOSHIOKA, Tatsunobu; JP
  • KATSUMA, Masataka; JP
Agents
  • NAGAI, Shozo ; Yamanouchi Pharmaceutical Co., Ltd. Patent Department 17-1, Hasune 3-chome Itabashi-ku, Tokyo 174-8612, JP
Priority Data
11/1392022.01.1999JP
11/1392522.01.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) MEDICINAL COMPOSITIONS WITH IMPROVED ORAL ABSORPTION
(FR) COMPOSITIONS MEDICAMENTEUSES PRESENTANT UNE MEILLEURE ABSORPTION ORALE
Abstract
(EN)
Medicinal compositions with improved absorption via digestive mucosae wherein a drug (in particular, a basic drug) which is hardly absorbed via digestive mucosae, when orally administered, is blended with a substance having an effect of inhibiting the formation of a hardly absorbable complex formed by the drug with bile acid or an effect of dissociating the complex; and a method for improving the digestive absorption of a drug. Spray-dried medicinal compositions containing an aminoalkyl methacrylate copolymer E and being handled conveniently, which are prepared by dissolving the above polymer and a surfactant in a solvent followed by spray-drying; and a process for producing these compositions.
(FR)
La présente invention concerne des compositions médicamenteuses mieux absorbées par les muqueuses digestives, où un médicament (en particulier, un médicament basique). difficilement absorbable par les muqueuses digestives lorsqu'il est administré oralement, est mélangé à une substance ayant soit une action inhibitrice sur la formation d'un complexe difficilement absorbable formé par le médicament et l'acide biliaire, soit une action de dissociation sur ce complexe. Par ailleurs, cette invention concerne une méthode d'amélioration de l'absorption médicamenteuse par voie digestive. En outre, l'invention concerne des compositions médicamenteuses atomisées contenant un copolymère de méthacrylate aminoalkyle E, préparées de façon appropriée, en dissolvant d'abord le polymère précité avec un tensioactif dans un solvant, et en les atomisant ensuite. Enfin, cette invention concerne un processus de production de ces compositions.
Also published as
Latest bibliographic data on file with the International Bureau