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1. WO2000043039 - VACCINE-MEDIATED TREATMENT OF NEUROLOGICAL DISORDERS

Publication Number WO/2000/043039
Publication Date 27.07.2000
International Application No. PCT/US2000/002016
International Filing Date 24.01.2000
Chapter 2 Demand Filed 21.08.2000
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
542oral/gastrointestinal
A61K 39/0007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0007Nervous system antigens; Prions
C07K 14/70571
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70571for neuromediators, e.g. serotonin receptor, dopamine receptor
C07K 16/286
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
286against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
Applicants
  • DURING, Matthew, John [US/US]; US
Inventors
  • DURING, Matthew, John; US
Agents
  • ENGELLENNER, Thomas, J. ; Nutter, McClennen & Fish, LLP One International Place Boston, MA 02110-2699, US
Priority Data
60/116,74822.01.1999US
60/127,14231.03.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VACCINE-MEDIATED TREATMENT OF NEUROLOGICAL DISORDERS
(FR) TRAITEMENT DE TROUBLES PSYCHOLOGIQUES A BASE DE VACCIN
Abstract
(EN)
A method of treating or preventing development of a neurological disorder has been developed wherein a subject with the disorder, or at risk of developing a disorder, is vaccinated against a brain protein or antigen. Alternatively, the antibodies can be directly administered to the individual in need of treatment thereof. Animal studies demonstrate potent efficacy in the treatment of epilepsy, stroke and cognition in animal models vaccinated against the NMDA receptor.
(FR)
On a développé une technique permettant de prévenir ou de traiter le développement ou le risque de développement d'un trouble neurologique chez un sujet, par vaccination dudit sujet contre une protéine cérébrale faisant fonction d'antigène. Selon un autre mode de réalisation, les anticorps sont directement administrés à un individu ayant besoin dudit traitement. Des études effectuées sur des animaux ont montré l'efficacité du traitement contre l'épilepsie, l'apoplexie et la cognition dans des modèles d'animaux vaccinés contre le récepteur du N-méthyle-D-aspartate (NMDA).
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