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1. WO2000043010 - ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF

Publication Number WO/2000/043010
Publication Date 27.07.2000
International Application No. PCT/US2000/001347
International Filing Date 21.01.2000
Chapter 2 Demand Filed 16.08.2000
IPC
C07D 213/69 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
69Two or more oxygen atoms
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
C07D 213/69
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
69Two or more oxygen atoms
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • SOUTHERN RESEARCH INSTITUTE [US/US]; 200 Ninth Avenue South Birmingham, AL 35205, US (AllExceptUS)
  • STRUCK, Robert, F. [US/US]; US (UsOnly)
Inventors
  • STRUCK, Robert, F.; US
Agents
  • AMERNICK, Burton, A. ; Pollock, Vande Sande & Amernick P.O. Box 19088 Washington, DC 20036, US
Priority Data
60/116,67521.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF
(FR) DERIVES ACYLE DE 4-DEMETHYLPENCLOMEDINE, LEUR UTILISATION ET PREPARATION
Abstract
(EN)
Acyl derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.
(FR)
L'invention porte sur des dérivés acyle de 4-déméthylpenclomédine ainsi que sur des compositions pharmaceutiques les contenant et sur leur utilisation dans le traitement du cancer. L'invention porte également sur un procédé de préparation de ces dérivés.
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