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1. WO2000043004 - 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS

Publication Number WO/2000/043004
Publication Date 27.07.2000
International Application No. PCT/US2000/001754
International Filing Date 26.01.2000
Chapter 2 Demand Filed 28.08.2000
IPC
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61K 51/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
C07B 59/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07F 13/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13Compounds containing elements of Groups 7 or 17 of the Periodic System
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 51/0497
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
0497conjugates with a carrier being an organic compounds
C07B 59/002
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
002Heterocyclic compounds
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
C07F 13/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13Compounds containing elements of Groups 7 or 17 of the Periodic System
005Compounds without a metal-carbon linkage
Applicants
  • FOX CHASE CANCER CENTER [US/US]; 7701 Burholme Avenue Philadelphia, PA 19111, US (AllExceptUS)
  • CHAPMAN, J., Donald [US/US]; US (UsOnly)
  • SCHNEIDER, Richard, F. [US/US]; US (UsOnly)
  • ENGELHARDT, Edward, L. [US/US]; US (UsOnly)
Inventors
  • CHAPMAN, J., Donald; US
  • SCHNEIDER, Richard, F.; US
  • ENGELHARDT, Edward, L.; US
Agents
  • HAGAN, Patrick, J. ; Dann, Dorfman, Herrell and Skillman Suite 720 1601 Market Street Philadelphia, PA 19103-2307, US
Priority Data
60/117,25326.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS
(FR) DERIVES 1,4,8,11-TETRAAZACYCLOTETRADECANE UTILES EN TANT QU'AGENTS DE RADIODIAGNOSTIC ET UTILISATION DE CES DERNIERS DANS LA DETERMINATION DE L'HYPOXIE ET DE LA RADIORESISTANCE DES TUMEURS
Abstract
(EN)
1,4,8,11-Tetraazacyclotetradecane which is chemically linked to from one to four nitroimidazol groups provides an effective radiodiagnostic agent for determining tissue hypoxia and radioresistance of tumor tissue.
(FR)
Du 1,4,8,11-tétraazaclyclotétradécane qui est chimiquement lié à un ou plusieurs groupes nitroimidazole dont le nombre peut varier entre un et quatre constitue un agent de radiodiagnostic efficace permettant de déterminer l'hypoxie tissulaire et la radiorésistance de tissus tumoraux.
Also published as
US09890036
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