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1. WO2000042994 - INHIBITION OF BACTERIAL DISSEMINATION

Publication Number WO/2000/042994
Publication Date 27.07.2000
International Application No. PCT/US2000/001340
International Filing Date 21.01.2000
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
CPC
A61K 2039/55572
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants
  • NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE [US/US]; Cornell University Medical College 350 Company Drive Manhasset, NY 11030, US (AllExceptUS)
  • GOYERT, Sanna, M. [US/US]; US (UsOnly)
  • SILVER, Jack [US/US]; US (UsOnly)
  • HAIZOT, Alain [FR/US]; US (UsOnly)
Inventors
  • GOYERT, Sanna, M.; US
  • SILVER, Jack; US
  • HAIZOT, Alain; US
Agents
  • COOPER, Iver, P.; Browdy and Neimark, P.L.L.C. Suite 300 624 Ninth Street, N.W. Washington, DC 20001, US
Priority Data
60/116,67121.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF BACTERIAL DISSEMINATION
(FR) INHIBITION DE LA DISSEMINATION DE BACTERIES
Abstract
(EN)
Bacterial dissemination is inhibited by administering a substance which accelerates recruitment of neutrophils to the peritoneal cavity and thereby inhibits bacterial dissemination from the peritoneal cavity lipids are of particular interest. Substances are preferably screened in normal and/or CDN deficient mice.
(FR)
Selon cette invention, on inhibe la dissémination de bactéries en administrant une substance qui accélère le recrutement de neutrophiles dans la cavité péritonéale et inhibe ainsi la dissémination des lipides de la cavité péritonéale. On recherche de préférence des substances dans des souris normales et/ou déficientes en CDN.
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