Processing

Please wait...

Settings

Settings

1. WO2000042993 - NONAQUEOUS SOLUTIONS AND SUSPENSIONS OF MACROMOLECULES FOR PULMONARY DELIVERY

Publication Number WO/2000/042993
Publication Date 27.07.2000
International Application No. PCT/US2000/000957
International Filing Date 14.01.2000
Chapter 2 Demand Filed 22.08.2000
IPC
A61K 9/72 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
72for smoking or inhaling
A61P 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
CPC
A61K 9/0078
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0078for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
A61K 9/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
008comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US
Inventors
  • KLIBANOV, Alexander, M.; US
Agents
  • PABST, Patrea, L. ; Arnall Golden & Gregory, LLP 2800 One Atlantic Center 1201 West Peachtree Street Atlanta, GA 30309-3450, US
Priority Data
09/443,71619.11.1999US
60/116,86022.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NONAQUEOUS SOLUTIONS AND SUSPENSIONS OF MACROMOLECULES FOR PULMONARY DELIVERY
(FR) SOLUTIONS ET SUSPENSIONS NON AQUEUSES DE MACROMOLECULES POUR ADMINISTRATION PAR VOIE PULMONAIRE
Abstract
(EN)
Methods and formulations for delivery of macromolecules, such as proteins, polysaccharides, and nucleic acids, are disclosed, where the macromolecule is dissolved or dispersed in a low toxicity organic solvent which can be aerosolized for delivery to a patient's lungs by inhalation. Optionally, appropriate solubility enhancers are also present in the formulations composition.
(FR)
Cette invention concerne des procédés et des formules concernant l'administration de macromolécules, telles que des protéines, des polysaccharides, et des acides nucléiques. La macromolécule est dissoute ou dispersée dans un solvant organique à faible toxicité, pouvant être diffusé par aérosol, ce qui permet son administration, par inhalation, aux poumons d'un patient. Des agents favorisant la solubilité peuvent également être présents dans la composition.
Latest bibliographic data on file with the International Bureau