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1. WO2000042988 - METHOD OF IDENTIFYING AND TREATING INFLAMED TISSUE

Publication Number WO/2000/042988
Publication Date 27.07.2000
International Application No. PCT/US2000/001277
International Filing Date 20.01.2000
IPC
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K 9/5052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5052Proteins, e.g. albumin
Applicants
  • UNIVERSITY OF VIRGINIA [US/US]; 1224 West Main Street, #1-110 Charlottesville, VA 22903, US
Inventors
  • LINDNER, Jonathan; US
  • COGGINS, Matthew; US
  • LEY, Klaus; US
  • KAUL, Sanjiv; US
Agents
  • REPPER, George, R. ; Rothwell, Figg, Ernst & Kurz Suite 701 East 555 13th Street N.W. Columbia Square Washington, DC 20004, US
Priority Data
60/116,79321.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF IDENTIFYING AND TREATING INFLAMED TISSUE
(FR) PROCEDE PERMETTANT DE RECONNAITRE UN TISSU ENFLAMME ET DE LE TRAITER
Abstract
(EN)
A method of identifying and/or treating tissue having leukocytes adhered thereto which utilizes a material that selectively attaches to leukocytes adhered to a patient's tissue. The material may be a gas-filled microbubble contrast agent which selectively attaches to activated leukocytes present in inflamed tissue. The microbubbles attached to activated leukocytes may be located by ultrasound echography, and inflamed tissue may be treated by a drug or gene sequence carried by the microbubble contrast agent.
(FR)
Cette invention a trait à un procédé permettant de reconnaître et/ou de traiter un tissu sur lequel adhèrent des leucocytes, lequel procédé fait appel à un matériau fixant, de manière sélective, des leucocytes adhérant au tissu d'un patient. Ce matériau peut être un agent de contraste microbulle rempli de gaz se fixant de manière sélective à des leucocytes activés présents dans un tissu enflammé. Il est possible de localiser les microbulles fixées aux leucocytes activés par échographie ultrasonique ainsi que de traiter le tissu enflammé à l'aide d'un médicament ou d'une séquence génique transportée par l'agent de contraste microbulle.
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