Processing

Please wait...

Settings

Settings

1. WO2000042431 - METHODS AND ASSAY KITS FOR DETECTING MONONUCLEAR CELL PHENOTYPE

Publication Number WO/2000/042431
Publication Date 20.07.2000
International Application No. PCT/US2000/000879
International Filing Date 13.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/56972
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56966Animal cells
56972White blood cells
Y10S 435/975
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
975Kit
Applicants
  • BIOCRYSTAL LTD. [US/US]; 575 McCorkle Boulevard Westerville, OH 43082-8888, US
Inventors
  • BARBERA-GUILLEM, Emilio; US
  • NELSON, M., Bud; US
Agents
  • NELSON, M., Bud; BioCrystal Ltd. 575 McCorkle Boulevard Westerville, OH 43082-8888, US
Priority Data
09/333,10315.06.1999US
09/435,28905.11.1999US
60/115,94614.01.1999US
60/117,89529.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND ASSAY KITS FOR DETECTING MONONUCLEAR CELL PHENOTYPE
(FR) DETECTION DE PHENOTYPE CELLULAIRE MONONUCLEAIRE ET KIT D'ESSAI A CET EFFET
Abstract
(EN)
A method for screening for a pro-tumor immune response according to the present invention, the method comprises: (a) contacting a clinical sample with one or more detector molecules for detecting, and then determining the amount of, mononuclear cell phenotype in the sample; and (b) comparing the amount of mononuclear cell phenotype determined in the sample to a reference value for the mononuclear cell phenotype; wherein a significant difference in the amount of mononuclear cell phenotype determined as compared to the reference value may be an indicator of the presence of a pro-tumor immune response. Also provided are assay kits for determining an amount of mononuclear cell phenotype in a clinical sample.
(FR)
La présente invention concerne un procédé de recherche systématique de réponse immunitaire protumorale. Ce procédé consiste (a) à faire un prélèvement clinique et à le mettre en contact avec au moins une molécule détectrice de façon à détecter le phénotype cellulaire mononucléaire dans le prélèvement et à en faire la numération. Le procédé consiste ensuite (b) à prendre la numération du phénotype cellulaire mononucléaire déterminée dans le prélèvement et à la comparer à une valeur de référence du phénotype cellulaire mononucléaire. En l'occurrence, tout écart sensible de la numération du phénotype cellulaire mononucléaire déterminée par rapport à la valeur de référence peut être une indication de la présence d'une réponse immunitaire protumorale. L'invention concerne également des kits d'essai permettant de déterminer dans un prélèvement clinique une numération de phénotype cellulaire mononucléaire.
Also published as
Latest bibliographic data on file with the International Bureau