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1. WO2000042429 - $i(IN VITRO) MODEL FOR GASTROINTESTINAL INFLAMMATION

Publication Number WO/2000/042429
Publication Date 20.07.2000
International Application No. PCT/IE2000/000009
International Filing Date 17.01.2000
Chapter 2 Demand Filed 03.08.2000
IPC
A23C 9/123 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
9Milk preparations; Milk powder or milk powder preparations
12Fermented milk preparations; Treatment using microorganisms or enzymes
123using only microorganisms of the genus lactobacteriaceae; Yoghurt
A61K 35/74 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
CPC
A23C 9/1234
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
9Milk preparations; Milk powder or milk powder preparations
12Fermented milk preparations; Treatment using microorganisms or enzymes
123using only microorganisms of the genus lactobacteriaceae; Yoghurt
1234characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
A23L 33/135
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A23Y 2220/77
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
YINDEXING SCHEME RELATING TO LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
2220Lactobacillus
77Sakei
A61K 2039/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
A61K 2039/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
542oral/gastrointestinal
Applicants
  • ENTERPRISE IRELAND [IE/IE]; Glasnevin Dublin 9, IE (AllExceptUS)
  • NATIONAL UNIVERSITY OF IRELAND, CORK [IE/IE]; College Road Cork, IE (AllExceptUS)
  • COLLINS, John, Kevin [IE/IE]; IE (UsOnly)
  • O'MAHONY, Liam [IE/IE]; IE (UsOnly)
Inventors
  • COLLINS, John, Kevin; IE
  • O'MAHONY, Liam; IE
Agents
  • O'BRIEN, John, A. ; John A. O'Brien & Associates Third Floor, Duncairn House 14 Carysfort Avenue Blackrock County Dublin, IE
Priority Data
99003315.01.1999IE
99078220.09.1999IE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) $i(IN VITRO) MODEL FOR GASTROINTESTINAL INFLAMMATION
(FR) MODELE $i(IN VITRO) RELATIF A UNE INFLAMMATION GASTRO-INTESTINALE
Abstract
(EN)
An $i(in vitro) test for testing the immunomodulatory especially anti-inflammatory or pro-inflammatory effect of a test material comprises placing a microporous support having a monolayer of epithelial cells therein in contact with a nutrient medium in a culture well. Cells of the immune system such as peripheral blood mononuclear cells are introduced into the medium and a test material is also introduced into the nutrient medium. A change in an immunological marker, especially a cytokine, particularly TNF$g(a) or IL-8 in response to the test material is determined. The test material may be a strain of $i(Lactobacillus) or $i(Bifidobacterium) or other material which may be a probiotic.
(FR)
Cet essai $i(in vitro) permettant d'éprouver l'action immunomodulatrice, notamment anti-inflammatoire ou de déclenchement d'une inflammation, d'une substance à examiner, consiste à mettre un support microporeux renfermant une monocouche de cellules épithéliales en contact avec un milieu nutritif dans une coupelle de culture. On introduit des cellules du système immun, par exemple des cellules mononucléaires du sang périphérique, ainsi que la substance à examiner dans ce milieu nutritif. On détermine une modification survenue dans un marqueur immunologique, notamment une cytokine, en particulier le facteur de nécrose tumorale alpha (TNF$g(a)) ou l'interleukine 8 (IL-8), en réaction à la substance à examiner. La substance à examiner peut être une souche de $i(Lactobacillus) ou de $i(Bifidobacterium) ou une autre substance pouvant être un probiotique.
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