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1. WO2000042216 - GENETIC PREDISPOSITION TO ABNORMAL CALCIFICATION CONDITIONS

Publication Number WO/2000/042216
Publication Date 20.07.2000
International Application No. PCT/EP2000/000319
International Filing Date 17.01.2000
Chapter 2 Demand Filed 11.08.2000
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • OSTEOMETER BIOTECH A/S [DK/DK]; OsteoPark Herlev Hovedgade 207 DK-2730 Herlev, DK (AllExceptUS)
  • KUSK, Philip [DK/DK]; DK (UsOnly)
Inventors
  • KUSK, Philip; DK
Agents
  • SMART, Peter, J.; W.H. Beck, Greener & Co. 7 Stone Buildings Lincoln's Inn London WC2A 3SZ, GB
Priority Data
9901037.318.01.1999GB
9912585.828.05.1999GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENETIC PREDISPOSITION TO ABNORMAL CALCIFICATION CONDITIONS
(FR) PREDISPOSITION GENETIQUE
Abstract
(EN)
Methods of assessing an individual's predisposition to abnormal calcification conditions such as osteoporosis by determining the genotype of a promoter for the bone sialoprotein gene, the matrix gla protein gene, the osteoponting gene or the osteoprotegerin gene individually or in any combination. Specific allelic variations for each promoter are described.
(FR)
Cette invention concerne des procédés permettant d'établir la prédisposition d'un individu à des conditions de calcification anormales, telle que l'ostéoporose, lesquels procédés consistent à déterminer le génotype d'un promoteur pour le gène de sialoprotéine des os, pour le gène de protéine gla matricielle, pour le gène d'ostéopontine ou pour le gène d'ostéoprotégérine, que se soit de manière individuelle ou combinée. Cette invention concerne également des variations alléliques spécifiques pour chaque promoteur.
Also published as
US09889491
Latest bibliographic data on file with the International Bureau