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1. WO2000042211 - METHODS OF SCREENING PROTEASE INHIBITORS, OF INDUCING MICE SUSCEPTIBLE TO HIV PROTEASE INHIBITOR-INDUCED DYSLIPIDEMIA, AND GENES ASSOCIATED THEREWITH

Publication Number WO/2000/042211
Publication Date 20.07.2000
International Application No. PCT/US2000/001205
International Filing Date 19.01.2000
Chapter 2 Demand Filed 12.07.2000
IPC
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A01K 2267/0306
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
0306Animal model for genetic diseases
A01K 2267/0362
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
035Animal model for multifactorial diseases
0362Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford, Middlesex UB6 0NN, GB (AllExceptUS)
  • LENHARD, James, Martin [US/US]; US (UsOnly)
Inventors
  • LENHARD, James, Martin; US
Agents
  • LEVY, David, J.; Glaxo Wellcome, Inc. Five Moore Drive P.O. Box 13398 Research Triangle Park, NC 27709-3398 , US
Priority Data
60/116,30019.01.1999US
60/137,62004.06.1999US
60/146,30927.07.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF SCREENING PROTEASE INHIBITORS, OF INDUCING MICE SUSCEPTIBLE TO HIV PROTEASE INHIBITOR-INDUCED DYSLIPIDEMIA, AND GENES ASSOCIATED THEREWITH
(FR) PROCEDES DE CRIBLAGE D'INHIBITEURS DE PROTEASE, D'INDUCTION DE SOURIS SENSIBLE A LA DYSLIPIDEMIE PROVOQUEE PAR LES INHIBITEURS DE PROTEASE DU VIH, ET GENES ASSOCIES A CEUX-CI
Abstract
(EN)
The present invention relates generally to the side effects caused by retroviral therapies, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and non-nucleoside reverse transcriptase inhibitors. Specifically, the present invention provides methods of screening a protease inhibitor for its capacity to affect symptoms or clinical conditions associated with lipodystrophy or dyslipidemia and related metabolic disorders, such as metabolic syndrome X, obesity, cardiovascular disorders, and impaired glucose tolerance in diabetes, in a patient.
(FR)
La présente invention concerne de manière générale les effets secondaires provoqués par les thérapies rétrovirales, notamment les inhibiteurs de protéase, les inhibiteurs nucléosidiques de transcriptase inverse, et les inhibiteurs non-nucléosidiques de transcriptase inverse. De manière plus spécifique, cette invention concerne des procédés de criblage d'inhibiteur de protéase pour sa capacité à affecter les symptômes ou les états cliniques associés à la lipodystrophie ou dyslipidémie et les troubles métaboliques connexes, comme par exemple le syndrome X métabolique, l'obésité, les troubles cardiovasculaires, et l'intolérance au glucose en cas de diabète, chez un patient.
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