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1. WO2000042189 - INTERLEUKIN-20

Publication Number WO/2000/042189
Publication Date 20.07.2000
International Application No. PCT/US2000/000807
International Filing Date 14.01.2000
Chapter 2 Demand Filed 02.08.2000
IPC
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 2799/026
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
026where the vector is derived from a baculovirus
Applicants
  • HUMAN GENOME SCIENCES, INC. [US/US]; 9410 Key West Avenue Rockville, MD 20850, US (AllExceptUS)
  • EBNER, Reinhard [DE/US]; US (UsOnly)
  • MURPHY, Marianne [US/GB]; GB (UsOnly)
  • RUBEN, Steven, M. [US/US]; US (UsOnly)
  • HU, Jing-Shan [CN/US]; US (UsOnly)
  • DUAN, D., Roxanne [US/US]; US (UsOnly)
  • FLORENCE, Kimberly [US/US]; US (UsOnly)
  • ROSEN, Craig, A. [US/US]; US (UsOnly)
Inventors
  • EBNER, Reinhard; US
  • MURPHY, Marianne; GB
  • RUBEN, Steven, M.; US
  • HU, Jing-Shan; US
  • DUAN, D., Roxanne; US
  • FLORENCE, Kimberly; US
  • ROSEN, Craig, A.; US
Agents
  • KENNY, Joseph, J. ; Human Genome Sciences, Inc. 9410 Key West Avenue Rockville, MD 20850, US
Priority Data
09/231,78815.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTERLEUKIN-20
(FR) INTERLEUKINE 20
Abstract
(EN)
The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombiant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
(FR)
La présente invention concerne une nouvelle protéine IL-20 qui appartient à la famille des cytokines polypeptides. On décrit plus particulièrement des molécules isolées d'acide nucléique codant la protéine IL-20 humaine; des polypeptides IL-20 ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de les produire; des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité de IL-20; des procédés de diagnostic permettant de détecter des troubles liés au système immunitaire et des procédés thérapeutiques permettant de traiter des troubles liés au système immunitaire.
Also published as
Latest bibliographic data on file with the International Bureau