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1. WO2000042170 - NOVEL LRSG PROTEIN AND NUCLEIC ACID MOLECULES AND USES THEREFOR

Publication Number WO/2000/042170
Publication Date 20.07.2000
International Application No. PCT/US1999/008792
International Filing Date 21.04.1999
Chapter 2 Demand Filed 15.11.1999
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street Cambridge, MA 02139, US
Inventors
  • HOLTZMAN, Douglas, A.; US
Agents
  • MANDRAGOURAS, Amy, E. ; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109, US
Priority Data
09/063,95021.04.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL LRSG PROTEIN AND NUCLEIC ACID MOLECULES AND USES THEREFOR
(FR) MOLECULES D'ACIDE NUCLEIQUE ET DE PROTEINE LRSG ET LEURS UTILISATIONS
Abstract
(EN)
Novel LRSG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length LRSG proteins, the invention further provides isolated LRSG fusion proteins, antigenic peptides and anti-LRSG antibodies. The invention also provides LRSG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an LRSG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
(FR)
Cette invention concerne des polypeptides, des protéines et des molécules d'acide nucléique LRSG. En plus des protéines LRSG complètes isolées, l'invention concerne des protéines de fusion LRSG isolées, des peptides antigéniques et des anticorps anti-LRSG. De plus, cette invention concerne des molécules d'acide nucléique LRSG, des vecteurs d'expression recombinants renfermant les molécules d'acide nucléique selon l'invention, des cellules hôtes dans lesquels ont été introduits les vecteurs d'expression, et des animaux transgéniques non humains chez lesquels le gène LRSG a été introduit ou invalidé. Sont également présentées des méthodes de diagniostic, de recherche systématique et de traitement faisant intervenir lesdites compositions.
Latest bibliographic data on file with the International Bureau