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1. WO2000042074 - ANTI-CCR4 ANTIBODIES AND METHODS OF USE THEREFOR

Publication Number WO/2000/042074
Publication Date 20.07.2000
International Application No. PCT/US2000/000917
International Filing Date 14.01.2000
Chapter 2 Demand Filed 21.07.2000
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/2866
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2866against receptors for cytokines, lymphokines, interferons
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 75 Sidney Street Cambridge, MA 02139, US (AllExceptUS)
  • WU, Lijun [CN/US]; US (UsOnly)
  • RUFFING, Nancy [US/US]; US (UsOnly)
  • ANDREW, David [GB/US]; US (UsOnly)
Inventors
  • WU, Lijun; US
  • RUFFING, Nancy; US
  • ANDREW, David; US
Agents
  • WENDLER, Helen, E. ; Hamilton, Brook, Smith & Reynolds, P.C. Two Militia Drive Lexington, MA 02421, US
Priority Data
09/231,75915.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-CCR4 ANTIBODIES AND METHODS OF USE THEREFOR
(FR) ANTICORPS ANTI-CCR4 ET LEUR UTILISATION
Abstract
(EN)
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
(FR)
L'invention concerne un anticorps ou un fragment fonctionnel dudit anticorps, qui se fixe sur le récepteur des chimiokines CC 4 (CCR4) de mammifère (par exemple l'homme) ou sur une partie dudit récepteur et qui empêche la fixation d'un ligand sur ledit récepteur. Elle concerne également une technique qui permet d'inhiber l'interaction d'une cellule portant un récepteur CCR4 de mammifère avec le ligand dudit récepteur, ainsi que l'utilisation desdits anticorps et fragments dans les domaines de la recherche, de la thérapeutique, de la prophylaxie et du diagnostic.
Latest bibliographic data on file with the International Bureau