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1. (WO2000042072) POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2000/042072 International Application No.: PCT/US2000/000973
Publication Date: 20.07.2000 International Filing Date: 14.01.2000
Chapter 2 Demand Filed: 03.08.2000
IPC:
C07K 16/00 (2006.01) ,C07K 16/22 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/42 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
22
against growth factors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42
against immunoglobulins (anti-idiotypic antibodies)
Applicants:
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990, US
Inventors:
PRESTA, Leonard, G.; US
Agent:
LEE, Wendy, M. ; Genentech, Inc. 1 DNA Way South San Francisco, CA 94080-4990, US
KIDDLE, Simon_et al. Mewburn Ellis; York House 23 Kingsway London WC2B 6HP, GB
Priority Data:
60/116,02315.01.1999US
Title (EN) POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
(FR) VARIANTS POLYPEPTIDIQUES AYANT UNE FONCTION EFFECTRICE ALTEREE
Abstract:
(EN) The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
(FR) La présente invention concerne des polypeptides comprenant un fragment Fc variant. L'invention concerne plus particulièrement des polypeptides à fragment Fc comportant une fonction effectrice altérée résultant d'une ou plusieurs modifications des acides aminés dans ledit fragment Fc.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ512770PLP.349770PLP.388183PLP.394232MXPA/a/2001/007170KR1020010102976
KR1020060067983ZA2001/05484KR1020080090572KR1020090078369IL144056BRPI0008758
KR1020100045527EP1141024JP2010227116EP2364997EP2366713EP2386574
JP2003512019 IL222149IL222150IL223047IL223048CN1343221
CN1763097JP2013166770CA2359067JP2016136951AU2000028505AU2012211437
MX353234ES2694002