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1. WO2000042067 - SACCHARIDES LINKED TO COMPOUNDS THAT BIND CELL-SURFACE PEPTIDES OR PROTEINS

Publication Number WO/2000/042067
Publication Date 20.07.2000
International Application No. PCT/US2000/000651
International Filing Date 12.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 1/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
04on carriers
C07K 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
9Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 1/047
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
04on carriers
047Simultaneous synthesis of different peptide species; Peptide libraries
C07K 9/008
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
9Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
006the peptide sequence being part of a ring structure
008directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Applicants
  • PRINCETON UNIVERSITY [US/US]; 5 New South Building P.O. Box 36 Princeton, NJ 08544-0036, US
Inventors
  • KAHNE, Daniel; US
Agents
  • VILLACORTA, Gilberto, M. ; Pepper Hamilton LLP 600 Fourtheenth Street, N.W. Washington, DC 20005-2004, US
Priority Data
60/115,59612.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SACCHARIDES LINKED TO COMPOUNDS THAT BIND CELL-SURFACE PEPTIDES OR PROTEINS
(FR) SACCHARIDES PORTES PAR DES COMPOSES SE LIANT A DES PROTEINES OU DES PEPTIDES CELLULAIRES DE SURFACE
Abstract
(EN)
A compound which comprises: (i) a saccharide compound having transglycosylase inhibitory activity; and (ii) a second compound that is capable of binding a protein or enzyme involved in cell wall biosynthesis, a precursor used in cell wall biosynthesis, the cell wall surface, or combinations thereof. The saccharide compound is linked directly or through a difunctional linker, to the non-saccharide compound; provided that: when the non-saccharide compound is a hexapeptide or a heptapeptide and the saccharide compound does not contain a phosphate or phosphonate ester, then the saccharide compound is not linked directly to the non-saccharide compound through a glycosidic linkage. The non-saccharide compound includes both 'natural' (aglycones that are typically associated with a carbohydrate moiety) and 'unnatural' (substances that are not typically associated with carbohydrate moiety) aglycones. Unnatural aglycones can be selected, for example, from peptide-binding dyes.
(FR)
La présente invention concerne un composé comprenant: (i) un composé saccharide présentant une activité inhibitrice de transglycosylase, et (ii) un second composé capable de se lier à une protéine ou à une enzyme impliquée en biosynthèse de paroi cellulaire, à un précurseur utilisé en biosynthèse de paroi cellulaire, à la surface de la paroi cellulaire, ou à des combinaisons de ces possibilités. Le composé saccharide est lié, directement ou au moyen d'un lieur bifonctionnel, au composé non saccharide, à condition que lorsque le composé non saccharide est un hexapeptide ou un heptapeptide et que le composé saccharide ne contient ni un ester phosphate ni un ester phosphonate, le composé saccharide ne soit pas lié directement au composé non saccharide via une liaison glycosidique. Le composé non saccharide comprend à la fois des aglycones 'naturels' (des aglycones typiquement associés à un reste hydrate de carbone) et des aglycones 'non naturels' (des substances non typiquement associées à un reste hydrate de carbone). Des aglycones non naturels peuvent être choisis, par exemple, parmi des colorants qui se lient à des peptides.
Also published as
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