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1. WO2000042054 - 2,3-O-ISOPROPYLIDENE DERIVATIVES OF MONOSACCHARIDES AS CELL ADHESION INHIBITORS

Publication Number WO/2000/042054
Publication Date 20.07.2000
International Application No. PCT/IB2000/000022
International Filing Date 10.01.2000
Chapter 2 Demand Filed 09.08.2000
IPC
C07H 9/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02the hetero ring containing only oxygen as ring hetero atoms
04Cyclic acetals
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
C07H 9/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02the hetero ring containing only oxygen as ring hetero atoms
04Cyclic acetals
Applicants
  • RANBAXY LABORATORIES LIMITED [IN/IN]; 19 Nehru Place New Delhi 110 019, IN (AllExceptUS)
  • ARORA, Sudershan, K. [IN/IN]; IN (UsOnly)
  • KISHORE, Nawal [IN/IN]; IN (UsOnly)
  • GUPTA, Jang, Bahadur [IN/IN]; IN (UsOnly)
  • JOSHI, Vishwas, D. [IN/IN]; IN (UsOnly)
Inventors
  • ARORA, Sudershan, K.; IN
  • KISHORE, Nawal; IN
  • GUPTA, Jang, Bahadur; IN
  • JOSHI, Vishwas, D.; IN
Priority Data
09/276,36825.03.1999US
86/DEL/9915.01.1999IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 2,3-O-ISOPROPYLIDENE DERIVATIVES OF MONOSACCHARIDES AS CELL ADHESION INHIBITORS
(FR) DERIVES 2, 3-O ISOPROPYLIDENE DE MONOSACCHARIDES INHIBANT L'ADHESION CELLULAIRE
Abstract
(EN)
This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O- isopropylidene-$g(a) -L-xylo-2- hexulofuranosonic acid, of formula (I) compounds of this invention are useful, inter-alia, for the inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases, such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection and psoriasis. This invention also relates to pharmacological compositions containing derivatives of 2-3-O- isopropylidene-$g(a) -L-xylo-2- hexulofuranosonic acid and the methods of treating such pathologies as listed above.
(FR)
De façon générale, cette invention concerne des composés et des méthodes permettant de synthétiser des dérivés d'acide 2-3-O-isopropylidène-$g(a)-L-xylo-2-hexulofuranosonique représenté par la formule (I). Ces composés favorisent, entre autres choses, l'inhibition et la prévention de l'adhésion cellulaire et des pathologies causées par l'adhésion cellulaire, dont les maladies inflammatoires et auto-immunes telles que l'asthme, la polyarthrite rhumatoïde, le diabète de type I, la sclérose en plaques, les rejets d'allogreffes et le psoriasis. L'invention concerne également des compositions pharmaceutiques renfermant des dérivés d'acide 2-3-O-isopropylidène-$g(a)-L-xylo-2-hexulofuranosonique et des méthodes de traitement des pathologies susmentionnées.
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