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1. WO2000042046 - ARTEMISININ ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE, AND ANTITUMOR ACTIVITIES AND CHEMOSELECTIVE METHODS OF MAKING THE SAME

Publication Number WO/2000/042046
Publication Date 20.07.2000
International Application No. PCT/US2000/000618
International Filing Date 11.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
C07D 493/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12in which the condensed system contains three hetero rings
18Bridged systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
CPC
C07D 493/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12in which the condensed system contains three hetero rings
18Bridged systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • HAUSER, INC. [US/US]; 5555 Airport Boulevard Boulder, CO 80301, US
  • JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, MD 21218-2685, US
Inventors
  • POSNER, Gary, H.; US
  • MURRAY, Christopher; US
  • O'DOWD, Hardwin; US
  • XIE, Suji; US
  • SHAPIRO, Theresa, A.; US
Agents
  • PETERSEN, Steven, C. ; Hogan & Hartson L.L.P. 1200 17th Street, Suite 1500 Denver, CO 80202, US
Priority Data
09/228,66812.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARTEMISININ ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE, AND ANTITUMOR ACTIVITIES AND CHEMOSELECTIVE METHODS OF MAKING THE SAME
(FR) COMPOSES DIMERES DE TRIOXANE PRESENTANT DES ACTIVITES ANTIPROLIFERATIVE, ET ANTITUMORALE
Abstract
(EN)
Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have structure (VII) or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is 1 and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
(FR)
L'invention concerne des techniques permettant de produire de nouveaux analogues et dimères d'artémisinine présentant des activités antimalariale, antiproliférative et antitumorale. Ces nouveaux analogues et dimères d'artémisinine sont représentés par la structure (VII). L'invention concerne également des diastéréomères desdites compositions, présentant des activités antimalariale, antiproliférative et antitumorale. Les monomères de l'invention sont formés lorsque n est égal à 1, et lorsque R représente alkyle, cycloalkyle, hétéroalkyle, hétérocycloalkyle, alcényle, alcynyle, aryle ou hétéroaryle. Les dimères de l'invention sont formés lorsque n est égal à 2, et lorsque R représente un liant comprenant notamment alkyle, cycloalkyle, hétéroalkyle, hétérocycloalkyle, alcényle, alcynyle, aryle ou hétéroaryle.
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