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1. WO2000042037 - TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY

Publication Number WO/2000/042037
Publication Date 20.07.2000
International Application No. PCT/EP2000/000176
International Filing Date 12.01.2000
Chapter 2 Demand Filed 11.08.2000
IPC
C07D 249/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12Oxygen or sulfur atoms
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
C07D 249/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12Oxygen or sulfur atoms
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Lugwigshafen, DE (AllExceptUS)
  • STARCK, Dorothea [DE/DE]; DE (UsOnly)
  • TREIBER, Hans-Jörg [DE/DE]; DE (UsOnly)
  • UNGER, Liliane [DE/DE]; DE (UsOnly)
  • NEUMANN-SCHULTZ, Barbara [DE/DE]; DE (UsOnly)
  • BLUMBACH, Kai [DE/DE]; DE (UsOnly)
  • SCHÖBEL, Dietmar [DE/DE]; DE (UsOnly)
Inventors
  • STARCK, Dorothea; DE
  • TREIBER, Hans-Jörg; DE
  • UNGER, Liliane; DE
  • NEUMANN-SCHULTZ, Barbara; DE
  • BLUMBACH, Kai; DE
  • SCHÖBEL, Dietmar; DE
Agents
  • KINZEBACH, Werner ; Ludwigsplatz 4 D-67059 Ludwigshafen, DE
Priority Data
199 00 811.612.01.1999DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) TRIAZOLVERBINDUNGEN MIT DOPAMIN-D3-REZEPTORAFFINITÄT
(EN) TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY
(FR) COMPOSES DE TRIAZOL PRESENTANT UNE AFFINITE POUR LE RECEPTEUR 3 DE LA DOPAMINE
Abstract
(DE)
Die vorliegende Erfindung betrifft Triazolverbindungen der Formel (I), worin R1, R2, A und B die in der Beschreibung angegebenen Bedeutungen besitzen. Die erfindungsgemäßen Verbindungen besitzen eine hohe Affinität zum Dopamin-D3-Rezeptor und sind daher zur Behandlung von Erkrankungen brauchbar, die auf die Beeinflussung durch Dopamin-D3-Liganden ansprechen.
(EN)
The invention relates to triazole compounds of formula (I), in which R1, R2, A and B have the meanings given in the description. The compounds provided for in the invention have a high affinity for the dopamine-D3-receptor and can therefore be used for the treatment of diseases which respond to the influence of dopamine-D3-ligands.
(FR)
L'invention concerne des composés de triazol de formule (I), dans laquelle R1, R2, A et B ont la signification indiquée dans la description. Ces composés présentent une grande affinité pour le récepteur D3 de la dopamine et s'utilisent par conséquent pour le traitement de maladies sur l'évolution desquelles peuvent influer les ligands au récepteur D3 de la dopamine.
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