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1. WO2000042027 - NOVEL POLYHYDROXYPYRAZINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/2000/042027
Publication Date 20.07.2000
International Application No. PCT/FR2000/000026
International Filing Date 07.01.2000
Chapter 2 Demand Filed 20.07.2000
IPC
C07D 241/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
CPC
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 21/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
02Muscle relaxants, e.g. for tetanus or cramps
C07D 241/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applicants
  • AVENTIS PHARMA S.A. [FR/FR]; 20, avenue Raymond-Aron F-92160 Antony, FR (AllExceptUS)
  • BOUCHARD, Hervé [FR/FR]; FR (UsOnly)
  • COMMERCON, Alain [FR/FR]; FR (UsOnly)
Inventors
  • BOUCHARD, Hervé; FR
  • COMMERCON, Alain; FR
Agents
  • MORVAN, Michèle; Aventis Pharma Direction des brevets - Tri LE1 144 20, avenue Raymond-Aron F-92165 Antony Cedex, FR
Priority Data
99/0018611.01.1999FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NOVEL POLYHYDROXYPYRAZINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) NOUVEAUX DERIVES DE POLYHYDROXYPYRAZINES, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Abstract
(EN)
The invention concerns novel derivatives of formula (I) wherein: R1 represents the stereoisomerical forms of the chain -(CHOH)3-CH2-O-COR (II) and either R2 represents a hydrogen atom and R3 represents the stereoisomerical forms of the chain -CH2-(CHOH)2-CH2-O-COR (III) or R2 represents the stereoisomerical forms of the chains -(CHOH)3-CH2-O-COR (II) or -CH2-(CHOH)2-CH2-O-COR (III) and R3 represents a hydrogen atom and R represents -(Alk)i-(Cycloalk) radical; i is equal to 0 or 1; Alk represents an alkyl radical, Cycloalk represents a cycloalkyl radical, and their salts with a mineral or organic acid, their preparation and the medicines containing as active principle at least a product of general formula (I) or its salts with a mineral or organic acid.
(FR)
Nouveaux dérivés de formule (I), dans laquelle: R1 représente les formes stéréoisomères de la chaîne -(CHOH)3-CH2-O-COR (II) et soit R2 représente un atome d'hydrogène et R3 représente les formes stéréoisomères de la chaîne -CH2-(CHOH)2-CH2-O-COR (III), soit R2 représente les formes stéréoisomères des chaînes -(CHOH)3-CH2-O-COR (II) ou -CH2-(CHOH)2-CH2-O-COR (III) et R3 représente un atome d'hydrogène, et R représente radical -(Alk)i-(Cycloalk); i est égal à 0 ou 1; Alk désigne un radical alkyle, Cycloalk désigne un radical cyloalkyle, et/ou leurs sels avec un acide minéral ou organique, leur préparation et les médicaments contenant en tant que principe actif au moins un produit de formule générale (I) ou ses sels avec un acide minéral ou organique.
Also published as
CZPV2001-2483
ININ/PCT/2001/00611/DEL
MGMGB200122
NO20013416
NZ512911
SK200100976
SK9762001
ZA200105657
Latest bibliographic data on file with the International Bureau