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1. WO2000042024 - CRYSTALLINE BIS[(E)-7- [ 4-(4- FLUOROPHENYL)- 6-ISOPROPYL-2- [METHYL (METHYLSULFONYL) AMINO] PYRIMIDIN -5-YL] (3R,5S)-3, 5-DIHYDROXYHEPT -6-ENOIC ACID]CALCIUM SALT

Publication Number WO/2000/042024
Publication Date 20.07.2000
International Application No. PCT/GB1999/004439
International Filing Date 23.12.1999
Chapter 2 Demand Filed 19.07.2000
IPC
C07D 239/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
CPC
C07D 239/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
Applicants
  • ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
  • TAYLOR, Nigel, Phillip [GB/GB]; GB (UsOnly)
Inventors
  • TAYLOR, Nigel, Phillip; GB
Agents
  • BRYANT, Tracey; Global Intellectual Property AstraZeneca P.O. Box 272, Mereside Alderley Park, Macclesfield Cheshire SK10 4GR, GB
Priority Data
9900339.409.01.1999GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CRYSTALLINE BIS[(E)-7- [ 4-(4- FLUOROPHENYL)- 6-ISOPROPYL-2- [METHYL (METHYLSULFONYL) AMINO] PYRIMIDIN -5-YL] (3R,5S)-3, 5-DIHYDROXYHEPT -6-ENOIC ACID]CALCIUM SALT
(FR) SEL CRISTALLIN DE CALCIUM BIS[(E)-7-[ 4-(4- FLUOROPHENYL)- 6-ISOPROPYL-2- [METHYL (METHYLSULFONYL) AMINO] PYRIMIDINE-5-YL] (3R,5S)-3, 5-DIHYDROXYHEPT -6-ACIDE ENOIQUE]
Abstract
(EN)
The present invention relates to a crystalline form of the compound bis[(E)-7-[ 4-(4- fluorophenyl)- 6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S)-3, 5-dihydroxyhept -6-enoic acid]calcium salt, as well as processes for its manufacture and pharmaceutical compositions comprising the crystalline form, which is useful as an agent for treating hyperlipidemia, hypercholesterolemia and atherosclerosis.
(FR)
L'invention concerne une forme cristalline du composé sel de calcium[(E)-7-[ 4-(4- fluorophényl)- 6-isopropyl-2- [méthyl (méthylsulfonyl) amino] pyrimidine-5-yl] (3R,5S)-3, 5-dihydroxyhept -6-acide énoïque], ainsi que ses procédés de fabrication et des composition pharmaceutiques comprenant ladite forme cristalline, utile en tant qu'agent pour le traitement de l'hyperlipidemie, l'hypercholestérolémie et l'athérosclérose.
Also published as
CZPV2001-2460
IN223/MUMNP/2003
ININ/PCT/2001/00758/MUM
IS5977
NO20013368
NZ512560
SK200100963
SK9632001
TR2001/01894
ZA200105187
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