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1. WO2000042012 - ω-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

Publication Number WO/2000/042012
Publication Date 20.07.2000
International Application No. PCT/US2000/000648
International Filing Date 12.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
C07C 275/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
C07C 275/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
30being further substituted by halogen atoms, or by nitro or nitroso groups
C07C 275/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
32being further substituted by singly-bound oxygen atoms
C07C 275/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
32being further substituted by singly-bound oxygen atoms
34having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
36with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
C07C 275/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
40being further substituted by nitrogen atoms not being part of nitro or nitroso groups
C07C 311/29 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
29having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
CPC
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
A61K 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 31/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
24having an amino or nitro group
A61K 31/341
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4035
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
4035Isoindoles, e.g. phthalimide
Applicants
  • BAYER CORPORATION [US/US]; 100 Bayer Road Pittsburgh, PA 15205, US (AllExceptUS)
  • RIEDL, Bernd [DE/DE]; DE (UsOnly)
  • DUMAS, Jacques [FR/US]; US (UsOnly)
  • KHIRE, Uday [IN/US]; US (UsOnly)
  • LOWINGER, Timothy, B. [CA/JP]; JP (UsOnly)
  • SCOTT, William, J. [US/US]; US (UsOnly)
  • SMITH, Roger, A. [CA/US]; US (UsOnly)
  • WOOD, Jill, E. [US/US]; US (UsOnly)
  • MONAHAN, Mary-Katherine [US/US]; US (UsOnly)
  • NATERO, Reina [US/US]; US (UsOnly)
  • RENICK, Joel [US/US]; US (UsOnly)
  • SIBLEY, Robert, N. [US/US]; US (UsOnly)
Inventors
  • RIEDL, Bernd; DE
  • DUMAS, Jacques; US
  • KHIRE, Uday; US
  • LOWINGER, Timothy, B.; JP
  • SCOTT, William, J.; US
  • SMITH, Roger, A.; US
  • WOOD, Jill, E.; US
  • MONAHAN, Mary-Katherine; US
  • NATERO, Reina; US
  • RENICK, Joel; US
  • SIBLEY, Robert, N.; US
Agents
  • TRAVERSO, Richard, J.; Millen, White, Zelano & Branigan, P.C. Arlington Courthouse Plaza 1 Suite 1400 2200 Clarendon Boulevard Arlington, VA 22201, US
Priority Data
09/257,26625.02.1999US
09/425,22822.10.1999US
60/115,87713.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ω-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
(FR) DIPHENYLUREES A SUBSTITUANTS $g(v)-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
Abstract
(EN)
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
(FR)
La présente invention concerne l'utilisation d'un groupe d'arylurées dans le traitement de maladies liées à la présence de kinase raf, ainsi que des compositions pharmaceutiques destinées à être utilisées dans de telles thérapies.
Also published as
BG10968800
CZPV2001-2489
CZPV2006-706
HRP20010580A
ININ/PCT/2001/00799/MUM
NO20013463
NO20055863
NZ513079
PLP.360085
PLP.386517
RSP-2010/0431
RSP-491/01
SK200100988
SK200605096
SK50962006
SK9882001
TR2001/02020
YUP-491/01
ZA200105751
Latest bibliographic data on file with the International Bureau