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1. WO2000041994 - 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS

Publication Number WO/2000/041994
Publication Date 20.07.2000
International Application No. PCT/US1999/030418
International Filing Date 21.12.1999
Chapter 2 Demand Filed 20.07.2000
IPC
C07C 229/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
52having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
54with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
56with amino and carboxyl groups bound in ortho- position
58having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
C07C 311/39 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
37having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
38having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
39having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
C07D 213/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
C07C 229/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
52having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
54with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
56with amino and carboxyl groups bound in ortho-position
58having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
C07C 311/39
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
37having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
38having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
39having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
Applicants
  • WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US (AllExceptUS)
  • BARRETT, Stephen, Douglas [US/US]; US (UsOnly)
  • TECLE, Haile [US/US]; US (UsOnly)
Inventors
  • BARRETT, Stephen, Douglas; US
  • TECLE, Haile; US
Agents
  • RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
  • MANSMANN, Ivo; Warner-Lambert Company Legal Division, Patent Dept. c/o Gödecke AG Mooswaldalle 1 D-79090 Freiburg, DE
Priority Data
60/115,67013.01.1999US
60/122,42102.03.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS
(FR) 4-ARYLAMINO, 4-ARYLOXY, ET 4-ARYLTHIO DIARYLAMINES ET LEURS DERIVES COMME INHIBITEURS SELECTIFS DE MEK
Abstract
(EN)
The invention provides compounds of formula (II), wherein Ar, R3, R4, R5, R6, R7, R8 and W have the meanings given in the description. They are selective MEK inhibitors.
(FR)
L'invention concerne les composés représentés par la formule (II). Ar, R3, R4, R5, R6, R7, R8 et W, qui sont des inhibiteurs sélectifs de MEK, ont la signification donnée dans le descriptif.
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