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1. WO2000041763 - TISSUE LOCALIZED DRUG DELIVERY APPARATUS AND PROCESS

Publication Number WO/2000/041763
Publication Date 20.07.2000
International Application No. PCT/US2000/000690
International Filing Date 11.01.2000
Chapter 2 Demand Filed 10.08.2000
IPC
A61B 17/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
A61M 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
25Catheters; Hollow probes
A61M 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
31Devices for introducing or retaining media, e.g. remedies, in cavities of the body
CPC
A61B 2017/22067
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22051with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
22065Functions of balloons
22067Blocking; Occlusion
A61M 2025/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
25Catheters; Hollow probes
0001for pressure measurement
0002with a pressure sensor at the distal end
A61M 2025/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
25Catheters; Hollow probes
0043characterised by structural features
0057Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
A61M 2025/1015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
25Catheters; Hollow probes
10Balloon catheters
1011Multiple balloon catheters
1015having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
A61M 2025/1052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
25Catheters; Hollow probes
10Balloon catheters
1043with special features or adapted for special applications
1052for temporarily occluding a vessel for isolating a sector
A61M 31/002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
31Devices for introducing or retaining media, e.g. remedies, in cavities of the body
002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Applicants
  • PHARMASPEC, INC. [US/US]; Suite 102 7901 168th Avenue N.E. Redmond, WA 98052, US
Inventors
  • SHMULEWITZ, Ascher; IL
Agents
  • BURSE, David, T.; Lyon & Lyon LLP Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
Priority Data
09/228,25711.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TISSUE LOCALIZED DRUG DELIVERY APPARATUS AND PROCESS
(FR) APPAREIL ET PROCEDE D'ADMINISTRATION LOCALISEE D'UN MEDICAMENT DANS UN TISSU
Abstract
(EN)
This invention is a tissue localized drug delivery device, and method for locally administering a drug substance to a specific vascular bed, the device having an occlusive means (15), and a drug delivery means (14), wherein the occlusive means (15) provides for a period of holding a high concentration of drug within a defined vascular space (4) before release into the general circulation; and significant diluted effects of any drug remaining in the defined vascular space (4). Specifically, the localized drug delivery process provides for increased residence time, control of drug pharmacokinetics, and pharmacodynamics of the drug substance within a defined vasculature or tissue, particularly within the central nervous system, the heart or any vascular location containing proliferative tissue.
(FR)
L'invention concerne un dispositif d'administration localisée d'un médicament dans un tissu, ainsi qu'un procédé d'administration locale d'un médicament dans un lit vasculaire spécifique. Ce dispositif comprend des moyens d'occlusion (15) et un moyen d'administration de médicament (14). Ce moyen d'occlusion (15) assure un temps de rétention d'un produit à forte concentration dans un espace vasculaire défini (4) avant d'être libéré dans la circulation générale, et des effets significatifs de dilution du médicament restant dans l'espace vasculaire défini (4). De manière spécifique, le processus d'administration de médicament localisée assure un temps de rétention supérieur, un contrôle de la pharmacocinétique des médicaments et la pharmacodynamique du médicament dans un système vasculaire ou un tissu défini, en particulier, dans le système nerveux central, le coeur ou dans tout emplacement vasculaire renfermant des tissus prolifératifs.
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