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1. WO2000041739 - ATTACHMENT OF ACID MOIETY-CONTAINING BIOMOLECULES TO ACTIVATED POLYMERIC SURFACES

Publication Number WO/2000/041739
Publication Date 20.07.2000
International Application No. PCT/US2000/001028
International Filing Date 14.01.2000
Chapter 2 Demand Filed 16.08.2000
IPC
A61L 27/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
08Materials for coatings
10Macromolecular materials
A61L 33/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
CPC
A61L 2400/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
18Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
A61L 33/0029
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
0005Use of materials characterised by their function or physical properties
0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
0029using an intermediate layer of polymer
Applicants
  • UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 210 Park Building Salt Lake City, UT 84112, US (AllExceptUS)
  • BRIGHAM YOUNG UNIVERSITY [US/US]; Provo, UT 84602, US (AllExceptUS)
  • PRESTWICH, Glenn, D. [US/US]; US (UsOnly)
  • PITT, William, G. [US/US]; US (UsOnly)
Inventors
  • PRESTWICH, Glenn, D.; US
  • PITT, William, G.; US
Agents
  • KIMPEL, Janice, A. ; Needle & Rosenberg, P.C. Suite 1200 The Candler Building 127 Peachtree Street, N.E. Atlanta, GA 30303-1811, US
  • KINKELDEY, H ; Maximilianstrasse 58 80538 Munich, DE
Priority Data
60/116,02115.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ATTACHMENT OF ACID MOIETY-CONTAINING BIOMOLECULES TO ACTIVATED POLYMERIC SURFACES
(FR) FIXATION DE BIOMOLECULES CONTENANT UNE FRACTION D'ACIDE A DES SURFACES POLYMERES ACTIVEES
Abstract
(EN)
Compositions comprising an activated polymeric substrate having an acid moiety-containing biomolecule covalently bonded via the acid moiety to the substrate are disclosed. Methods for making such compositions are also provided, including methods that involve plasma processing of the substrate prior to the attachment of the biomolecule. These compositions find use as novel biomaterials, e.g. for tissue engineering and the prevention of adhesions, for selective attachment and growth of specific cell types, for coating surgically-implanted materials, and in coating vessels for storage of blood and blood products.
(FR)
L'invention concerne des compositions renfermant un substrat polymère activé qui comporte une biomolécule contenant une fraction d'acide liée de manière covalente par la fraction d'acide au substrat. L'invention concerne également des procédés de fabrication de ces compositions, y compris des procédés comportant un traitement par plasma du substrat avant fixation de la biomolécule. Ces compositions sont utiles comme nouvelles biomatières, p. ex. pour le génie tissulaire et la prévention des adhérences, pour la fixation et la croissance sélectives de types de cellules spécifiques, pour revêtir des matières implantées chirurgicales, et pour revêtir des récipients servant au stockage de sang et de produits sanguins.
Also published as
Latest bibliographic data on file with the International Bureau