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1. WO2000041732 - HYDROGEL COMPOSITIONS FOR CONTROLLED DELIVERY OF VIRUS VECTORS AND METHODS OF USE THEREOF

Publication Number WO/2000/041732
Publication Date 20.07.2000
International Application No. PCT/US2000/001194
International Filing Date 19.01.2000
Chapter 2 Demand Filed 15.06.2000
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 47/6903
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6903the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
Y10S 977/80
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
977Nanotechnology
70Nanostructure
788Of specified organic or carbon-based composition
797Lipid particle
798having internalized material
799Containing biological material
80Nucleic acid, e.g. DNA or RNA
Applicants
  • THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US/US]; Abramson Pediatric Research Center Room 132 34th & Civic Center Boulevard Philadelphia, PA 19104, US (AllExceptUS)
  • LEVY, Robert, J. [US/US]; US (UsOnly)
  • CROMBLEHOLME, Timothy [US/US]; US (UsOnly)
  • VYAVAHARE, Narendra [IN/US]; US (UsOnly)
Inventors
  • LEVY, Robert, J.; US
  • CROMBLEHOLME, Timothy; US
  • VYAVAHARE, Narendra; US
Agents
  • BENT, Stephen, A.; Foley & Lardner Suite 500 3000 K Street, NW Washington, DC 20007-5109, US
Priority Data
60/116,53819.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYDROGEL COMPOSITIONS FOR CONTROLLED DELIVERY OF VIRUS VECTORS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS HYDROGEL POUR L'ADMINISTRATION CONTROLEE DE VECTEURS VIRAUX, ET LEURS PROCEDES D'UTILISATION
Abstract
(EN)
The invention relates to compositions and methods for delivering a virus vector to an animal. The compositions include compositions which comprise a hydrogel matrix (e.g. a collagen matrix which can comprise a poloxamer or an alginate) containing a virus vector therein in a transfectious form. The invention also includes methods of making such hydrogel precursor mixtures and hydrogel matrices, including particles, devices, bulk materials, and other objects which comprise, consist of, or are coated with such mixtures or matrices. The invention further relates to compositions comprising a hydrogel precursor mixture having a virus vector suspended therein, which, when administered to an animal, gel to form a hydrogel matrix containing a virus vector therein in a transfectious form. Methods of delivering a virus vector to an animal tissue are also described.
(FR)
La présente invention concerne des compositions et des procédés d'administration d'un vecteur viral à un animal. Ces compositions contiennent des compositions renfermant une matrice hydrogel (par exemple une matrice de collagène pouvant comprendre un poloxamère ou un alginate) contenant un vecteur viral se présentant sous une forme transfectieuse. En outre, cette invention concerne des procédés de préparation de ce type de mélanges de précurseurs hydrogel et de matrices hydrogel, y compris les particules, dispositifs, matières en vrac, et autres objets qui consistent, contiennent ou sont enrobées de ces matrices ou mélanges. De plus, cette invention concerne des compositions contenant un mélange de précurseur hydrogel auquel est suspendu un vecteur viral, qui, lorsqu'il est administré à un animal, se gélifie pour former une matrice hydrogel contenant un vecteur viral se présentant sous une forme transfectieuse. De plus, cette invention concerne des procédés d'administration d'un vecteur viral dans un tissu animal.
Also published as
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