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1. WO2000041718 - METHOD AND APPARATUS FOR SELECTIVELY REMOVING XENOREACTIVE ANTIBODIES FROM BLOOD, SERUM OR PLASMA

Publication Number WO/2000/041718
Publication Date 20.07.2000
International Application No. PCT/US2000/000410
International Filing Date 10.01.2000
Chapter 2 Demand Filed 11.08.2000
IPC
A61M 1/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B01J 20/28 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
28characterised by their form or physical properties
B01J 20/32 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating or reactivating
32Impregnating or coating
CPC
A61M 1/3472
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3472with treatment of the filtrate
A61M 1/3475
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3472with treatment of the filtrate
3475with filtrate treatment agent in the same enclosure as the membrane
A61M 1/3486
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
3472with treatment of the filtrate
3486Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
B01J 20/28033
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
28characterised by their form or physical properties
28014characterised by their form
28033Membrane, sheet, cloth, pad, lamellar or mat
B01J 20/3204
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating, or reactivating
32Impregnating or coating ; ; Solid sorbent compositions obtained from processes involving impregnating or coating
3202characterised by the carrier, support or substrate used for impregnation or coating
3204Inorganic carriers, supports or substrates
B01J 20/321
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating, or reactivating
32Impregnating or coating ; ; Solid sorbent compositions obtained from processes involving impregnating or coating
3202characterised by the carrier, support or substrate used for impregnation or coating
3206Organic carriers, supports or substrates
3208Polymeric carriers, supports or substrates
321consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
Applicants
  • BAXTER INTERNATIONAL, INC. [US/US]; One Baxter Parkay Deerfield, Illinois 60015, US
Inventors
  • KAROOR, Sujatha; US
  • HENDERSON, Lee; US
  • MOLINA, Jeanette; US
Agents
  • SCHULMAN, B., Aaron; Larson & Taylor, PLC Suite 900 1199 North Fairfax Street Alexandria, VA 22314, US
Priority Data
09/227,54011.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND APPARATUS FOR SELECTIVELY REMOVING XENOREACTIVE ANTIBODIES FROM BLOOD, SERUM OR PLASMA
(FR) METHODE ET DISPOSITIF PERMETTANT D'EXTRAIRE SELECTIVEMENT DES ANTICORPS XENOREACTIFS DU SANG, DU SERUM OU DU PLASMA
Abstract
(EN)
A method and apparatus for selectively removing xenoreactive antibodies from blood, serum or plasma are provided wherein a ligand capable of binding to xenoreactive antibodies is immobilized to an immunoaffinity membrane, and the blood, serum or plasma is passed through the ligand-containing immunoaffinity membrane so that xenoreactive antibodies are removed from the blood, serum or plasma prior to its reintroduction into a patient. The invention allows for specific removal of only those xenoreactive antibodies associated with the hyperacute rejection observed when organs or tissues from certain non-human animals come in contact with human blood or blood fluids, as would occur during xenotransplantation. The invention is advantageous in that it can be carried out simply and efficiently using a single piece of equipment, and the invention will be useful in reducing or eliminating the hyperacute rejection and rapid destruction of graft tissue that would normally occur following xenotransplantation.
(FR)
Cette invention concerne une méthode et un dispositif permettant d'extraire sélectivement des anticorps xénoréactifs du sang, du sérum ou du plasma. Sur une membrane à immunoaffinité, on immobilise un ligand capable de se lier à un anticorps xénoréactif présent dans le sang, le sérum ou le plasma. En traversant la membrane à immunoaffinité renfermant le ligand, le sang, le sérum ou le plasma abandonnent les anticorps xénoréactifs avant d'être réintroduits dans l'organisme. Grâce à cette invention, il est possible d'extraire uniquement les anticorps xénoréactifs qui sont liés au rejet hyperaigu observable lorsque des organes ou des tissus de certains animaux non humains entrent en contact avec du sang ou des liquides sanguins, notamment pendant une xénotransplantation. Cette invention offre l'avantage de pouvoir être mise en oeuvre simplement et efficacement avec un seul matériel. Elle convient tout particulièrement bien pour réduire ou éliminer les risques de rejets hyperaigus et la destruction rapide de tissus greffés normalement observables après une xénotransplantation.
Also published as
Latest bibliographic data on file with the International Bureau