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1. WO2000041712 - INHIBITING DEVELOPMENT OF MICROVESSELS WITHIN VASCULAR WALLS

Publication Number WO/2000/041712
Publication Date 20.07.2000
International Application No. PCT/US2000/000161
International Filing Date 05.01.2000
Chapter 2 Demand Filed 15.08.2000
IPC
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 38/179
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
179for growth factors; for growth regulators
A61K 38/1891
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1891Angiogenesic factors; Angiogenin
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • CARDIOVASCULAR RESEARCH FOUNDATION [US/US]; 6th Floor 55 East 59th Street New York, NY 10022, US
Inventors
  • EPSTEIN, Stephen, E.; US
  • KORNOWSKI, Ran; US
  • FUCHS, Shmuel; US
  • LEON, Martin; US
Agents
  • KOWALSKI, Thomas, J.; Frommer Lawrence & Haug LLP 745 Fifth Avenue New York, NY 10151, US
Priority Data
60/115,97715.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITING DEVELOPMENT OF MICROVESSELS WITHIN VASCULAR WALLS
(FR) INHIBITION DU DEVELOPPEMENT DE VAISSEAUX MICROSCOPIQUES DANS DES PAROIS VASCULAIRES
Abstract
(EN)
Disclosed and claimed are compositions and methods for therapy and/or prevention of restenosis and/or atherosclerosis. The compositions can include an agent for inhibiting VEGF and an agent for inducing vessel maturation; for instance, the soluble VEGF receptor and ang-1. Embodiments can include kits.
(FR)
Cette invention a trait à des compositions et aux méthodes correspondantes de traitement et/ou de prévention de la resténose et/ou de l'athérosclérose. Ces compositions peuvent renfermer un agent d'inhibition du facteur de croissance endothéliale (VEGF) et un agent déclenchant une maturation des vaisseaux, par exemple le récepteur du VGEF soluble et ang-1. Certaines réalisations comprennent des kits.
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