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1. WO2000041711 - METHODS FOR INHIBITING TUMOR METASTASIS, AND PEPTIDES USEFUL THEREFOR

Publication Number WO/2000/041711
Publication Date 20.07.2000
International Application No. PCT/US2000/001012
International Filing Date 14.01.2000
Chapter 2 Demand Filed 20.07.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • THE BURNHAM INSTITUTE [US/US]; 10901 North Torrey Pines Road La Jolla, CA 92037, US (AllExceptUS)
  • FUKUDA, Michiko [JP/JP]; US (UsOnly)
  • FUKUDA, Minoru [JP/JP]; US (UsOnly)
Inventors
  • FUKUDA, Michiko; US
  • FUKUDA, Minoru; US
Agents
  • RAMOS, Robert, T. ; Campbell & Flores LLP Suite 700 4370 La Jolla Village Drive San Diego, CA 92122, US
Priority Data
09/232,48415.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR INHIBITING TUMOR METASTASIS, AND PEPTIDES USEFUL THEREFOR
(FR) METHODES POUR INHIBER UNE METASTASE TUMORALE, ET PEPTIDES POUVANT ETRE UTILISES A CETTE FIN
Abstract
(EN)
In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit the adhesion of cells containing particular cell-surface carbohydrates to cells containing cell-surface selectins. Also provided are pharmaceutical compositions comprising invention peptides useful in methods for inhibiting a carbohydrate from binding to a selectin, and in methods of inhibiting tumor cell metastasis in a subject.
(FR)
Les peptides de l'invention se lient à un élément de la famille des sélectines mammaliennes et inhibent la liaison d'un glucide à la sélectine. Les peptides de l'invention peuvent être utilisés pour inhiber l'adhésion de cellules contenant des glucides de surface à des cellules contenant des sélectines de surface. L'invention concerne également des compositions pharmaceutiques contenant les peptides de l'invention. Ces compositions peuvent être utilisées dans des méthodes destinées à inhiber la liaison d'un glucide à une sélectine, ou dans des méthodes destinées à inhiber la métastase de cellules tumorales chez un sujet.
Latest bibliographic data on file with the International Bureau