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1. WO2000041689 - TELOMERASE INHIBITORS

Publication Number WO/2000/041689
Publication Date 20.07.2000
International Application No. PCT/JP2000/000105
International Filing Date 12.01.2000
Chapter 2 Demand Filed 04.08.2000
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/409 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
C07D 487/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22in which the condensed system contains four or more hetero rings
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/409
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
C07D 487/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
22in which the condensed system contains four or more hetero rings
Applicants
  • KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome Chiyoda-ku Tokyo 100-8185, JP (AllExceptUS)
  • YAMASHITA, Yoshinori [JP/JP]; JP (UsOnly)
  • ASAI, Akira [JP/JP]; JP (UsOnly)
  • HASEGAWA, Atsuhiro [JP/JP]; JP (UsOnly)
  • AKINAGA, Shiro [JP/JP]; JP (UsOnly)
  • ISHIDA, Hiroyuki [JP/JP]; JP (UsOnly)
  • MIZUKAMI, Tamio [JP/JP]; JP (UsOnly)
  • YAMAGUCHI, Hiroyuki [JP/JP]; JP (UsOnly)
  • AKAMA, Tsutomu [JP/JP]; JP (UsOnly)
  • ENDO, Kaori [JP/JP]; JP (UsOnly)
  • NARA, Shinji [JP/JP]; JP (UsOnly)
  • KANDA, Yutaka [JP/JP]; JP (UsOnly)
Inventors
  • YAMASHITA, Yoshinori; JP
  • ASAI, Akira; JP
  • HASEGAWA, Atsuhiro; JP
  • AKINAGA, Shiro; JP
  • ISHIDA, Hiroyuki; JP
  • MIZUKAMI, Tamio; JP
  • YAMAGUCHI, Hiroyuki; JP
  • AKAMA, Tsutomu; JP
  • ENDO, Kaori; JP
  • NARA, Shinji; JP
  • KANDA, Yutaka; JP
Priority Data
11/481312.01.1999JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) TELOMERASE INHIBITORS
(FR) INHIBITEURS DE TELOMERASE
Abstract
(EN)
Telomerase inhibitors containing as the active ingredient porphyrin derivatives represented by general formula (I), N-(lower alkyl)-substituted derivatives thereof (wherein the lower alkyl is located on the nitrogen atom of the pyrrole ring of the porphyrin ring) or metal coordinates thereof or pharmacologically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and each represents hydrogen, formyl, optionally substituted lower alkyl, optionally substituted lower alkenyl, carboxy, optionally substituted lower alkoxycarbonyl, CONR9R10 (wherein R9 and R10 are the same or different and each represents hydrogen or optionally substituted lower alkyl), sulfo, lower alkoxysulfonyl or cyano.
(FR)
La présente invention concerne des inhibiteurs de télomérase contenant, comme principe actif, des dérivés de porphyrine représentés par la formule générale (1) suivante, des dérivés à substituants N-(alkyle inférieur) de ces derniers (dans lesquels l'alkyle inférieur est situé sur l'atome d'azote du cycle pyrrole du cycle porphyrine) ou des composés métalliques coordonnés ou des sels pharmacologiquement acceptables de ces derniers : (1) dans laquelle R1, R2, R3, R4, R5, R6, R7 et R8 sont les mêmes ou différents, chacun représentant un hydrogène, un formyle, un alkyle inférieur facultativement substitué, un alcényle inférieur facultativement substitué, un carboxy, un alcoxycarbonyle facultativement substitué, CONR9R10 (où R9 et R10 sont les mêmes ou différents, chacun représentant un hydrogène ou un alkyle inférieur facultativement substitué), un sulfo, un alcoxysulfonyle inférieur ou un cyano.
Also published as
US09889057
Latest bibliographic data on file with the International Bureau