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1. WO2000041682 - LIPOPHILIC MICROPARTICLES CONTAINING A PROTEIN DRUG OR ANTIGEN AND FORMULATION COMPRISING SAME

Publication Number WO/2000/041682
Publication Date 20.07.2000
International Application No. PCT/KR2000/000025
International Filing Date 14.01.2000
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 9/113 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
113Multiple emulsions, e.g. oil-in-water-in-oil
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 38/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
CPC
A61K 38/212
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons ; [IFN]
212IFN-alpha
A61K 38/27
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
27Growth hormone [GH] (Somatotropin)
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 9/113
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
113Multiple emulsions, e.g. oil-in-water-in-oil
A61K 9/1617
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
Applicants
  • LG CHEMICAL LIMITED [KR/KR]; #20, Yoido-dong Yongdungpo-gu Seoul 150-721, KR (AllExceptUS)
  • KIM, Myung, Jin [KR/KR]; KR (UsOnly)
  • KIM, Sun, Jin [KR/KR]; KR (UsOnly)
  • KWON, Kyu, Chan [KR/KR]; KR (UsOnly)
  • KIM, Joon [KR/KR]; KR (UsOnly)
Inventors
  • KIM, Myung, Jin; KR
  • KIM, Sun, Jin; KR
  • KWON, Kyu, Chan; KR
  • KIM, Joon; KR
Agents
  • JANG, Seong, Ku; 17th Floor, KEC Building #275-7, Yangjae-dong Seocho-ku Seoul 137-130, KR
Priority Data
1999/123218.01.1999KR
1999/5977621.12.1999KR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIPOPHILIC MICROPARTICLES CONTAINING A PROTEIN DRUG OR ANTIGEN AND FORMULATION COMPRISING SAME
(FR) MICROPARTICLES LIPOPHILES CONTENANT UN MEDICAMENT OU UN ANTIGENE PROTEIQUE ET PREPARATION LES CONTENANT
Abstract
(EN)
A lipophilic microparticle having an average particle size ranging from 0.1 to 200 μm, comprising a lipophilic substance and an active ingredient selected from the group consisting of a protein or peptide drug and an antigen, retains the full activity of the active ingredient, and when formulated in the form of an oil dispersion or oil-in-water emulsion, it releases in an in vivo environment the active ingredient in a controlled manner over a long period.
(FR)
L'invention concerne une microparticle lipophile dont la granulométrie moyenne est comprise entre 0,1 et 200 $g(m)m, renfermant une substance lipophile et un principe actif sélectionné dans le groupe constitué d'une protéine, d'un peptide ou d'un médicament peptidique et d'un antigène. Cette microparticule maintient l'activité complète du principe actif et une fois formulée sous forme de dispersion huileuse ou d'émulsion huile-dans-eau, elle lâche le principe actif dans un environnement $i(in vivo) de manière régulée sur une longue période.
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