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1. WO2000041677 - GRANULES FOR ORAL ADMINISTRATION, PROCESS FOR PRODUCING THE SAME, AND TABLETS PRODUCED FROM THE GRANULES

Publication Number WO/2000/041677
Publication Date 20.07.2000
International Application No. PCT/JP2000/000059
International Filing Date 11.01.2000
Chapter 2 Demand Filed 27.07.2000
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 38/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
CPC
A61K 38/556
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
556Angiotensin converting enzyme inhibitors
A61K 9/1623
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Y10S 530/833
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
530Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
827Proteins from mammals or birds
833Whey; cheese
Applicants
  • CALPIS CO., LTD [JP/JP]; 20-3, Ebisu Nishi 2-chome, Shibuya-ku Tokyo 150-0021, JP
Inventors
  • KITAMURA, Shuji; JP
  • UEYAMA, Takashi; JP
Agents
  • TABUCHI, Hajimu; Fonte Aoyama Room 404 22-14, Minami Aoyama 2-chome, Minato-ku Tokyo 107-0062, JP
Priority Data
11/413211.01.1999JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GRANULES FOR ORAL ADMINISTRATION, PROCESS FOR PRODUCING THE SAME, AND TABLETS PRODUCED FROM THE GRANULES
(FR) GRANULES DESTINES A ETRE ADMINISTRES PAR VOIE ORALE, PROCEDE DE FABRICATION ASSOCIE ET COMPRIMES OBTENUS A PARTIR DESDITS GRANULES
Abstract
(EN)
Granules and tablets for oral administration, containing angiotensin-converting enzyme inhibiting peptides and treated whey with a mixing fluid bed processor, wherein said whey is obtained from lactic acid fermentation liquid. The granules have properties of narrow particle distributions, low moisture absorption, and heavy specific gravity, as well as high free flowing. A process is also provided for producing the granules by the steps of: a) onto seed granules obtained in an earlier operation in a mixing fluid bed processor, spraying purified whey of lactic acid fermentation liquid to form preliminary granules; b) treating the preliminary granules thus obtained to reduce particle size in a size reduction mill; c) returning the treated powder to the mixing fluid bed processor, and, d) spraying additional purified whey onto the returned powder in the mixing fluid bed processor to form granules, while fluidizing the said powder.
(FR)
L'invention concerne des granules et des comprimés destinés à être administrés par voie orale, contenant des peptides inhibiteurs de l'enzyme de conversion de l'angiotensine ainsi que du lactosérum traité avec une machine de traitement et de mélange à lit fluidisé, ledit lactosérum étant obtenu à partir d'un liquide de fermentation d'acide lactique. Lesdits granules présentent une distribution particulaire étroite, une faible absorption d'humidité, une forte densité ainsi qu'un écoulement fluide élevé. L'invention concerne également un procédé de fabrication desdits granules consistant a) à pulvériser du lactosérum purifié issu d'un liquide de fermentation d'acide lactique sur des granules germes issus d'une précédente opération dans une machine de traitement et de mélange à lit fluidisé, afin de former des granules préliminaires; b) à traiter les granules préliminaires ainsi obtenus afin de réduire leur taille particulaire dans un broyeur de réduction de taille; c) à réintroduire la poudre traitée dans la machine de traitement et de mélange à lit fluidisé et d) à pulvériser du lactosérum purifié supplémentaire sur la poudre réintroduite dans la machine de traitement et de mélange à lit fluidisé afin de former des granules, tout en fluidisant ladite poudre.
Also published as
NZ512719
Latest bibliographic data on file with the International Bureau