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1. WO2000041516 - REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE BREAST

Publication Number WO/2000/041516
Publication Date 20.07.2000
International Application No. PCT/US2000/001309
International Filing Date 19.01.2000
Chapter 2 Demand Filed 07.08.2000
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Road, IL 60064-6050, US
Inventors
  • BILLING-MEDEL, Patricia, A.; US
  • COHEN, Maurice; US
  • COLPITTS, Tracey, L.; US
  • FRIEDMAN, Paula, N.; US
  • GORDON, Julian; US
  • GRANADOS, Edward, N.; US
  • HODGES, Steven, C.; US
  • KLASS, Michael, R.; US
  • KRATOCHVIL, Jon, D.; US
  • ROBERTS-RAPP, Lisa; US
  • RUSSELL, John, C.; US
  • SCHEFFEL, Christi, P.; US
  • STROUPE, Stephen, D.; US
Agents
  • BECKER, Cheryl, L. ; Abbott Laboratories CHAD 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-6050, US
Priority Data
09/233,69319.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE BREAST
(FR) REACTIFS ET PROCEDES UTILES A LA DETECTION DES PATHOLOGIES MAMMAIRES
Abstract
(EN)
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, $i(in vivo) imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
(FR)
L'invention se rapporte à un ensemble de séquences d'ADNc contiguës et partiellement chevauchantes ainsi qu'à des peptides codés par ces séquences, lesdites séquences étant dénommées BU101 et transcrites à partir de tissu mammaire. Ces séquences sont utiles pour déceler, diagnostiquer, déterminer le stade, surveiller, prévoir, imager $i(in vivo), prévenir ou traiter, ou déterminer la prédisposition d'un sujet à des pathologies ou troubles mammaires, du type cancer du sein. L'invention concerne également des anticorps qui se lient de manière spécifique à la protéine ou au polypeptide codé par BU101, ainsi que des agonistes et des inhibiteurs qui bloquent l'action du polypeptide BU101 spécifique d'un tissu, lesdites molécules étant utiles au traitement thérapeutique des cancers du sein et des tumeurs ou métastases mammaires.
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