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1. WO2000041514 - CONJUGATES OF COLONY STIMULATING FACTORS FOR TARGETING AND IMAGING INFECTION AND INFLAMMATION

Publication Number WO/2000/041514
Publication Date 20.07.2000
International Application No. PCT/US2000/001289
International Filing Date 19.01.2000
Chapter 2 Demand Filed 18.08.2000
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 51/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
CPC
A61K 47/642
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
642the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
A61K 51/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
A61K 51/088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
088conjugates with carriers being peptides, polyamino acids, proteins
Applicants
  • BIOSTREAM, INC. [US/US]; 160 Second Street Cambridge, MA 02142, US (AllExceptUS)
  • BABICH, John, W. [US/US]; US (UsOnly)
Inventors
  • BABICH, John, W.; US
Agents
  • ARNOLD, Beth, E.; Foley, Hoag & Eliot LLP One Post Office Square Boston, MA 02109, US
Priority Data
60/116,36419.01.1999US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONJUGATES OF COLONY STIMULATING FACTORS FOR TARGETING AND IMAGING INFECTION AND INFLAMMATION
(FR) NOUVEAUX COMPOSES PERMETTANT LE CIBLAGE ET LA PRODUCTION D'IMAGES D'INFECTIONS ET D'INFLAMMATIONS
Abstract
(EN)
The present invention provides novel agents for specifically targeting and detecting or treating focal sites of infection or inflammation in a subject. The diagnostic agents of the invention rapidly localize at sites of infection or inflammation. In addition, the agents exhibit a relatively high target-to-background ratio and rapid clearance from the background and the target particular when administered as a bolus intravenously. Further, clinical pharmakonetic studies indicate that administration of colony stimulating factors in an amount effective for targeting would be relatively safe. The invention is based, at least in part, on the surprising finding that radiolabeled G-CSF effectively localizes to sites of infection. This empirical result is surprising, since the expression level of CSF receptors on cells has been found to be relatively low, compared to the expression level of other growth factor receptors on hematopoietic cells (Park et al., 'Hemapoietic Growth-Factor Receptors' p. 39-75 in). Based on the cross-reactivity between CSFs and CSF receptors (Walker, F., and A.W. Burgess (1987) J. Cell. Physiol. 130:255-261), it is expected that other CSFs will also bind to sites of infection.
(FR)
La présente invention se rapporte à de nouveaux agents qui sont destinés spécifiquement à cibler et détecter ou traiter des sites focaux d'infection ou d'inflammation chez un sujet.
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